Orofacial movements in phospholipase C-related catalytically inactive protein-1/2 double knockout mice: Effect of the GABAergic agent diazepam and the D1 dopamine receptor agonist SKF 83959

• Published in: Synapse (New York, N.Y.) N.Y.), 2010-09, Vol.64 (9), p.714-720
• Main Authors: Tomiyama, Katsunori, Song, Liqiu, Kobayashi, Masayuki, Kinsella, Anthony, Kanematsu, Takashi, Hirata, Masato, Koshikawa, Noriaki, Waddington, John L.
• Format: Article
• Language: English
• Subjects: Cell surface; D1 receptors; Diazepam; Dopamine D1 receptors; GABAA receptors; gamma -Aminobutyric acid A receptors; Head; Incisors; Jaw; phenotype; Phospholipase C; PRIP-1/2 knockout; Receptor mechanisms; SKF 83959; Synapses; Tongue
• ISSN: 0887-4476; 1098-2396; 1098-2396
• DOI: 10.1002/syn.20798

Orofacial movements are regulated by D1‐like dopamine receptors interacting with additional mechanisms. Phospholipase C‐related catalytically inactive protein (PRIP) regulates cell surface expression of GABAA receptors containing a γ2 subunit. Mutant mice with double knockout of PRIP‐1 and PRIP‐2 were used to investigate aspects of GABAergic regulation of orofacial movements and interactions with D1 mechanisms. Vertical jaw movements, tongue protrusions and movements of the head and vibrissae were reduced in PRIP‐1/2 double knockouts. The GABAAergic agent diazepam reduced movements of the head and vibrissae; these effects were unaltered in PRIP‐1/2 double knockouts. The D1‐like agonist SKF 83959 induced vertical jaw movements, incisor chattering, and movements of the head and vibrissae that were unaltered in PRIP‐1/2 double knockouts. However, SKF 83959‐induced tongue protrusions were reduced in PRIP‐1/2 double knockouts. PRIP‐mediated regulation of GABAAergic receptor mechanisms influences topographically distinct aspects of orofacial movement and interacts with D1 receptor systems. Synapse 64:714–720, 2010. © 2010 Wiley‐Liss, Inc.