Serum cytokine levels and periodontal parameters in ankylosing spondylitis

• Published in: Journal of periodontal research 2012-06, Vol.47 (3), p.396-401
• Main Authors: Sezer, U., Erciyas, K., Pehlivan, Y., Üstün, K., Tarakçıoğlu, M., Şenyurt, S. Z., Onat, A. M.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age; Ankylosing spondylitis; Baths; Biological and medical sciences; Bleeding; Blood; Body Mass Index; C-reactive protein; C-Reactive Protein - analysis; Case-Control Studies; Chronic Periodontitis - blood; cytokine; Cytokines; Cytokines - blood; Dental Plaque Index; Dentistry; Diseases of the osteoarticular system; Diseases of the spine; Female; Gingival Hemorrhage - blood; Humans; Inflammation; Inflammatory diseases; Inflammatory joint diseases; Interleukin 6; Interleukin-6 - blood; Male; Medical sciences; Middle Aged; Otorhinolaryngology. Stomatology; Periodontal Attachment Loss - blood; Periodontal diseases; periodontal parameter; Periodontal Pocket - blood; Periodontitis; Plaque index; serum; Spondylitis, Ankylosing - blood; Spondylitis, Ankylosing - classification; Statistical analysis; Tumor necrosis factor- alpha; Tumor Necrosis Factor-alpha - blood; Young Adult
• ISSN: 0022-3484; 1600-0765
• DOI: 10.1111/j.1600-0765.2011.01448.x

Sezer U, Erciyas K, Pehlivan Y, Üstün K, Tarakçıoğlu M, Şenyurt SZ, Onat AM. Serum cytokine levels and periodontal parameters in ankylosing spondylitis. J Periodont Res 2012; 47: 396–401. © 2011 John Wiley & Sons A/S Background and Objective:  Multiple studies support the role of periodontal disease in contributing to the chronic systemic inflammatory burden in a variety of diseases, including ankylosing spondylitis (AS), in the progression which the inflammatory process plays an important role. We assume that patients with AS are more likely to have periodontal disease than healthy individuals. The aim of this study was to determine the possible relationship between inflammatory periodontal diseases and AS by evaluating clinical periodontal parameters and serum cytokine levels. Material and Methods:  Forty‐eight adults with AS (35 women and 13 men; age range 18–56 years; mean age 34.27 years) and 48 age‐ and sex‐matched systemically healthy control subjects participated in the study. The clinical periodontal parameters, venous blood and Bath Ankylosing Spondylitis Disease Activity Score were obtained, and serum C‐reactive protein, tumour necrosis factor‐α and interleukin‐6 (IL‐6) levels were evaluated. Results:  There was statistically no significant difference in the frequency of periodontitis between AS patients and the control group. Furthermore, there was no significant difference in probing depth, clinical attachment level and plaque index, and the only significant clinical difference between groups was in levels of bleeding on probing (p