Mangosteen xanthones, α-and γ-mangostins, inhibit allergic mediators in bone marrow-derived mast cell

• Published in: Food chemistry 2012-09, Vol.134 (1), p.397-400
• Main Authors: Chae, Hee-Sung, Oh, Sei-Ryang, Lee, Hyeong-Kyu, Joo, Sang Hoon, Chin, Young-Won
• Format: Article
• Language: English
• Subjects: Allergy; Biological and medical sciences; Bone marrow; Bone marrow derived mast cell; bones; Cyclooxygenase-2; Degranulation; dietary supplements; Food industries; foods; Fruit and vegetable industries; Fundamental and applied biological sciences. Psychology; Garcinia Mangostana; hypersensitivity; Interleukin-6; interleukins; Leukotriene C4; mast cells; Prostaglandin D2; prostaglandin synthase; prostaglandins; traditional medicine; xanthones; α-Mangostin; γ-Mangostin
• ISSN: 0308-8146; 1873-7072
• DOI: 10.1016/j.foodchem.2012.02.075

► Mangosteen xanthones inhibited allergic mediators in bone marrow derived mast cells. ► Production of IL-6, PGD2 and LTC4, degranulation of histamine, and COX-2 expression were suppressed by α-and γ-mangostins. ► The present results suggest potentials of α-and γ-mangostins as anti-allergic molecules. Mangosteen (Garcinia mangostana L.), one of top-selling botanical dietary supplements in the USA, has been used as food and folk medicines in southeastern Asia. Herein, α-and γ-mangostins, major constituents of mangosteen, were investigated for their effect on the bone marrow-derived mast cell (BMMC) mediated allergy mechanism induced by phorbol 12-myristate 13-acetate (PMA) plus A23187. α- and γ-mangostins demonstrated to inhibit Interleukin (IL)-6, prostaglandin D2 (PGD2) and leukotriene C4 (LTC4) production as well as degranulation in PMA plus A23187 induced BMMC. Furthermore, α- and γ-mangostins were found to repress cyclooxygenase (COX)-2 expression in the present study. Thus, these results suggest that α- and γ-mangostins may be useful in alleviating mast cell-mediated allergic inflammatory responses.