Influence of Maternal Hyperglycemia on IL-10 and TNF-α Production: The Relationship with Perinatal Outcomes

Aims This study was conducted to evaluate maternal and placental concentrations of interleukin 10 (IL-10) and tumor necrosis factor-alpha (TNF-α) in pregnant women with glycemic mean (GM) < or ≥100 mg/dL, as well as correlate IL-10 and TNF-α placental concentrations with perinatal outcomes. Metho...

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Bibliographic Details
Published in:Journal of clinical immunology 2012-06, Vol.32 (3), p.604-610
Main Authors: Moreli, Jusciele Brogin, Morceli, Glilciane, De Luca, Ana Karina C., Magalhães, Claudia G., Costa, Roberto A. A., Damasceno, Débora Cristina, Rudge, Marilza Vieira Cunha, Calderon, Iracema Mattos Paranhos
Format: Article
Language:English
Subjects:
Adult
Biomedical and Life Sciences
Biomedicine
Blood
Diabetes Mellitus, Type 2 - immunology
Diabetes, Gestational - immunology
Female
Fetuses
Hemoglobin
Humans
Hyperglycemia
Hyperglycemia - immunology
Immunology
Infant, Newborn
Infectious Diseases
Insulin
Insulin - blood
Interleukin 10
Interleukin-10 - blood
Interleukin-10 - immunology
Internal Medicine
Medical Microbiology
Oxygen - metabolism
Placenta
Placenta - immunology
Pregnancy
Pregnancy in Diabetics - immunology
Tumor necrosis factor- alpha
Tumor Necrosis Factor-alpha - blood
Tumor Necrosis Factor-alpha - immunology
Umbilical cord
Young Adult
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Summary:Aims This study was conducted to evaluate maternal and placental concentrations of interleukin 10 (IL-10) and tumor necrosis factor-alpha (TNF-α) in pregnant women with glycemic mean (GM) < or ≥100 mg/dL, as well as correlate IL-10 and TNF-α placental concentrations with perinatal outcomes. Methods One hundred eighty-six pregnant women were distributed in groups determined by a GM
ISSN:0271-9142
1573-2592
DOI:10.1007/s10875-011-9634-3