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Influence of Maternal Hyperglycemia on IL-10 and TNF-α Production: The Relationship with Perinatal Outcomes
Aims This study was conducted to evaluate maternal and placental concentrations of interleukin 10 (IL-10) and tumor necrosis factor-alpha (TNF-α) in pregnant women with glycemic mean (GM) < or ≥100 mg/dL, as well as correlate IL-10 and TNF-α placental concentrations with perinatal outcomes. Metho...
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| Published in: | Journal of clinical immunology 2012-06, Vol.32 (3), p.604-610 |
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| container_end_page | 610 |
| container_issue | 3 |
| container_start_page | 604 |
| container_title | Journal of clinical immunology |
| container_volume | 32 |
| creator | Moreli, Jusciele Brogin Morceli, Glilciane De Luca, Ana Karina C. Magalhães, Claudia G. Costa, Roberto A. A. Damasceno, Débora Cristina Rudge, Marilza Vieira Cunha Calderon, Iracema Mattos Paranhos |
| description | Aims
This study was conducted to evaluate maternal and placental concentrations of interleukin 10 (IL-10) and tumor necrosis factor-alpha (TNF-α) in pregnant women with glycemic mean (GM) < or ≥100 mg/dL, as well as correlate IL-10 and TNF-α placental concentrations with perinatal outcomes.
Methods
One hundred eighty-six pregnant women were distributed in groups determined by a GM |
| doi_str_mv | 10.1007/s10875-011-9634-3 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1017971196</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1017971196</sourcerecordid><originalsourceid>FETCH-LOGICAL-c377t-db8e580f948cae03423eda5d82f6fb8c32879c00c9db4215d17922ba0982995d3</originalsourceid><addsrcrecordid>eNqNkcFu1DAQhi0EotvCA3BBPnIxjO14HXNDVUtXWmiFlrPlOJNuqsRe7ERoH4sX4ZlwtC1HxGk0mu__D_MR8obDew6gP2QOtVYMOGdmLSsmn5EVV1oyoYx4TlYgdLnwSpyR85wfAECuhXpJzoQQoARUKzJsQjfMGDzS2NEvbsIU3EBvjgdM98PR49g7GgPdbBkH6kJLd1-v2e9f9C7FdvZTH8NHutsj_YaDW7a87w_0Zz_t6R2mPriptN3Ok48j5lfkReeGjK8f5wX5fn21u7xh29vPm8tPW-al1hNrmxpVDZ2pau8QZCUktk61tejWXVN7KWptPIA3bVMJrlqujRCNA1MLY1QrL8i7U-8hxR8z5smOffY4DC5gnLPlUBKa8_K0_0ClXmstF5SfUJ9izgk7e0j96NKxQHbxYU8-bPFhFx9Wlszbx_q5GbH9m3gSUABxAnI5hXtM9iHOi4L8j9Y_5maVAg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1013767736</pqid></control><display><type>article</type><title>Influence of Maternal Hyperglycemia on IL-10 and TNF-α Production: The Relationship with Perinatal Outcomes</title><source>Springer Nature</source><creator>Moreli, Jusciele Brogin ; Morceli, Glilciane ; De Luca, Ana Karina C. ; Magalhães, Claudia G. ; Costa, Roberto A. A. ; Damasceno, Débora Cristina ; Rudge, Marilza Vieira Cunha ; Calderon, Iracema Mattos Paranhos</creator><creatorcontrib>Moreli, Jusciele Brogin ; Morceli, Glilciane ; De Luca, Ana Karina C. ; Magalhães, Claudia G. ; Costa, Roberto A. A. ; Damasceno, Débora Cristina ; Rudge, Marilza Vieira Cunha ; Calderon, Iracema Mattos Paranhos</creatorcontrib><description>Aims
This study was conducted to evaluate maternal and placental concentrations of interleukin 10 (IL-10) and tumor necrosis factor-alpha (TNF-α) in pregnant women with glycemic mean (GM) < or ≥100 mg/dL, as well as correlate IL-10 and TNF-α placental concentrations with perinatal outcomes.
Methods
One hundred eighty-six pregnant women were distributed in groups determined by a GM <100 mg/dL or a GM ≥100 mg/dL. The GM, HbA1c levels, maternal and placental concentrations of IL-10 and TNF-α, and the correlation of placental cytokines with perinatal outcomes were evaluated.
Results
In maternal blood, the lowest concentrations of IL-10 (
p
= 0.0019) and TNF-α (
p
= 0.0185) were observed in the GM ≥100-mg/dL group. The placentas from GM ≥100 mg/dL group exhibited higher TNF-α concentrations (
p
= 0.0385). Placental IL-10 directly correlated with hemoglobin (
r
= 0.63;
p
= 0.02) and insulin (
r
= 0.78;
p
= 0.01) levels in the umbilical cord and with 1-min (
r
= 0.53;
p
= 0.0095) and 5-min (
r
= 0.69;
p
= 0.0003) Apgar scores. Placental TNF-α displayed a tendency to inversely correlate with fetal weight (
r
= −0.41;
p
= 0.05).
Conclusion
Compared to GM <100 mg/dL, GM ≥100 mg/dL was associated with a reduction in maternal IL-10 and TNF-α concentrations and increased placental TNF-α production. Placental IL-10 production was similar in both groups studied and directly correlated with hemoglobin and umbilical cord insulin levels, as well as with the 1- and 5-min Apgar scores.</description><identifier>ISSN: 0271-9142</identifier><identifier>EISSN: 1573-2592</identifier><identifier>DOI: 10.1007/s10875-011-9634-3</identifier><identifier>PMID: 22205204</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Biomedical and Life Sciences ; Biomedicine ; Blood ; Diabetes Mellitus, Type 2 - immunology ; Diabetes, Gestational - immunology ; Female ; Fetuses ; Hemoglobin ; Humans ; Hyperglycemia ; Hyperglycemia - immunology ; Immunology ; Infant, Newborn ; Infectious Diseases ; Insulin ; Insulin - blood ; Interleukin 10 ; Interleukin-10 - blood ; Interleukin-10 - immunology ; Internal Medicine ; Medical Microbiology ; Oxygen - metabolism ; Placenta ; Placenta - immunology ; Pregnancy ; Pregnancy in Diabetics - immunology ; Tumor necrosis factor- alpha ; Tumor Necrosis Factor-alpha - blood ; Tumor Necrosis Factor-alpha - immunology ; Umbilical cord ; Young Adult</subject><ispartof>Journal of clinical immunology, 2012-06, Vol.32 (3), p.604-610</ispartof><rights>Springer Science+Business Media, LLC 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-db8e580f948cae03423eda5d82f6fb8c32879c00c9db4215d17922ba0982995d3</citedby><cites>FETCH-LOGICAL-c377t-db8e580f948cae03423eda5d82f6fb8c32879c00c9db4215d17922ba0982995d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22205204$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moreli, Jusciele Brogin</creatorcontrib><creatorcontrib>Morceli, Glilciane</creatorcontrib><creatorcontrib>De Luca, Ana Karina C.</creatorcontrib><creatorcontrib>Magalhães, Claudia G.</creatorcontrib><creatorcontrib>Costa, Roberto A. A.</creatorcontrib><creatorcontrib>Damasceno, Débora Cristina</creatorcontrib><creatorcontrib>Rudge, Marilza Vieira Cunha</creatorcontrib><creatorcontrib>Calderon, Iracema Mattos Paranhos</creatorcontrib><title>Influence of Maternal Hyperglycemia on IL-10 and TNF-α Production: The Relationship with Perinatal Outcomes</title><title>Journal of clinical immunology</title><addtitle>J Clin Immunol</addtitle><addtitle>J Clin Immunol</addtitle><description>Aims
This study was conducted to evaluate maternal and placental concentrations of interleukin 10 (IL-10) and tumor necrosis factor-alpha (TNF-α) in pregnant women with glycemic mean (GM) < or ≥100 mg/dL, as well as correlate IL-10 and TNF-α placental concentrations with perinatal outcomes.
Methods
One hundred eighty-six pregnant women were distributed in groups determined by a GM <100 mg/dL or a GM ≥100 mg/dL. The GM, HbA1c levels, maternal and placental concentrations of IL-10 and TNF-α, and the correlation of placental cytokines with perinatal outcomes were evaluated.
Results
In maternal blood, the lowest concentrations of IL-10 (
p
= 0.0019) and TNF-α (
p
= 0.0185) were observed in the GM ≥100-mg/dL group. The placentas from GM ≥100 mg/dL group exhibited higher TNF-α concentrations (
p
= 0.0385). Placental IL-10 directly correlated with hemoglobin (
r
= 0.63;
p
= 0.02) and insulin (
r
= 0.78;
p
= 0.01) levels in the umbilical cord and with 1-min (
r
= 0.53;
p
= 0.0095) and 5-min (
r
= 0.69;
p
= 0.0003) Apgar scores. Placental TNF-α displayed a tendency to inversely correlate with fetal weight (
r
= −0.41;
p
= 0.05).
Conclusion
Compared to GM <100 mg/dL, GM ≥100 mg/dL was associated with a reduction in maternal IL-10 and TNF-α concentrations and increased placental TNF-α production. Placental IL-10 production was similar in both groups studied and directly correlated with hemoglobin and umbilical cord insulin levels, as well as with the 1- and 5-min Apgar scores.</description><subject>Adult</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood</subject><subject>Diabetes Mellitus, Type 2 - immunology</subject><subject>Diabetes, Gestational - immunology</subject><subject>Female</subject><subject>Fetuses</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Hyperglycemia - immunology</subject><subject>Immunology</subject><subject>Infant, Newborn</subject><subject>Infectious Diseases</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>Interleukin 10</subject><subject>Interleukin-10 - blood</subject><subject>Interleukin-10 - immunology</subject><subject>Internal Medicine</subject><subject>Medical Microbiology</subject><subject>Oxygen - metabolism</subject><subject>Placenta</subject><subject>Placenta - immunology</subject><subject>Pregnancy</subject><subject>Pregnancy in Diabetics - immunology</subject><subject>Tumor necrosis factor- alpha</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Tumor Necrosis Factor-alpha - immunology</subject><subject>Umbilical cord</subject><subject>Young Adult</subject><issn>0271-9142</issn><issn>1573-2592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqNkcFu1DAQhi0EotvCA3BBPnIxjO14HXNDVUtXWmiFlrPlOJNuqsRe7ERoH4sX4ZlwtC1HxGk0mu__D_MR8obDew6gP2QOtVYMOGdmLSsmn5EVV1oyoYx4TlYgdLnwSpyR85wfAECuhXpJzoQQoARUKzJsQjfMGDzS2NEvbsIU3EBvjgdM98PR49g7GgPdbBkH6kJLd1-v2e9f9C7FdvZTH8NHutsj_YaDW7a87w_0Zz_t6R2mPriptN3Ok48j5lfkReeGjK8f5wX5fn21u7xh29vPm8tPW-al1hNrmxpVDZ2pau8QZCUktk61tejWXVN7KWptPIA3bVMJrlqujRCNA1MLY1QrL8i7U-8hxR8z5smOffY4DC5gnLPlUBKa8_K0_0ClXmstF5SfUJ9izgk7e0j96NKxQHbxYU8-bPFhFx9Wlszbx_q5GbH9m3gSUABxAnI5hXtM9iHOi4L8j9Y_5maVAg</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Moreli, Jusciele Brogin</creator><creator>Morceli, Glilciane</creator><creator>De Luca, Ana Karina C.</creator><creator>Magalhães, Claudia G.</creator><creator>Costa, Roberto A. A.</creator><creator>Damasceno, Débora Cristina</creator><creator>Rudge, Marilza Vieira Cunha</creator><creator>Calderon, Iracema Mattos Paranhos</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20120601</creationdate><title>Influence of Maternal Hyperglycemia on IL-10 and TNF-α Production: The Relationship with Perinatal Outcomes</title><author>Moreli, Jusciele Brogin ; Morceli, Glilciane ; De Luca, Ana Karina C. ; Magalhães, Claudia G. ; Costa, Roberto A. A. ; Damasceno, Débora Cristina ; Rudge, Marilza Vieira Cunha ; Calderon, Iracema Mattos Paranhos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-db8e580f948cae03423eda5d82f6fb8c32879c00c9db4215d17922ba0982995d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood</topic><topic>Diabetes Mellitus, Type 2 - immunology</topic><topic>Diabetes, Gestational - immunology</topic><topic>Female</topic><topic>Fetuses</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Hyperglycemia - immunology</topic><topic>Immunology</topic><topic>Infant, Newborn</topic><topic>Infectious Diseases</topic><topic>Insulin</topic><topic>Insulin - blood</topic><topic>Interleukin 10</topic><topic>Interleukin-10 - blood</topic><topic>Interleukin-10 - immunology</topic><topic>Internal Medicine</topic><topic>Medical Microbiology</topic><topic>Oxygen - metabolism</topic><topic>Placenta</topic><topic>Placenta - immunology</topic><topic>Pregnancy</topic><topic>Pregnancy in Diabetics - immunology</topic><topic>Tumor necrosis factor- alpha</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Tumor Necrosis Factor-alpha - immunology</topic><topic>Umbilical cord</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moreli, Jusciele Brogin</creatorcontrib><creatorcontrib>Morceli, Glilciane</creatorcontrib><creatorcontrib>De Luca, Ana Karina C.</creatorcontrib><creatorcontrib>Magalhães, Claudia G.</creatorcontrib><creatorcontrib>Costa, Roberto A. A.</creatorcontrib><creatorcontrib>Damasceno, Débora Cristina</creatorcontrib><creatorcontrib>Rudge, Marilza Vieira Cunha</creatorcontrib><creatorcontrib>Calderon, Iracema Mattos Paranhos</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moreli, Jusciele Brogin</au><au>Morceli, Glilciane</au><au>De Luca, Ana Karina C.</au><au>Magalhães, Claudia G.</au><au>Costa, Roberto A. A.</au><au>Damasceno, Débora Cristina</au><au>Rudge, Marilza Vieira Cunha</au><au>Calderon, Iracema Mattos Paranhos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Maternal Hyperglycemia on IL-10 and TNF-α Production: The Relationship with Perinatal Outcomes</atitle><jtitle>Journal of clinical immunology</jtitle><stitle>J Clin Immunol</stitle><addtitle>J Clin Immunol</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>32</volume><issue>3</issue><spage>604</spage><epage>610</epage><pages>604-610</pages><issn>0271-9142</issn><eissn>1573-2592</eissn><abstract>Aims
This study was conducted to evaluate maternal and placental concentrations of interleukin 10 (IL-10) and tumor necrosis factor-alpha (TNF-α) in pregnant women with glycemic mean (GM) < or ≥100 mg/dL, as well as correlate IL-10 and TNF-α placental concentrations with perinatal outcomes.
Methods
One hundred eighty-six pregnant women were distributed in groups determined by a GM <100 mg/dL or a GM ≥100 mg/dL. The GM, HbA1c levels, maternal and placental concentrations of IL-10 and TNF-α, and the correlation of placental cytokines with perinatal outcomes were evaluated.
Results
In maternal blood, the lowest concentrations of IL-10 (
p
= 0.0019) and TNF-α (
p
= 0.0185) were observed in the GM ≥100-mg/dL group. The placentas from GM ≥100 mg/dL group exhibited higher TNF-α concentrations (
p
= 0.0385). Placental IL-10 directly correlated with hemoglobin (
r
= 0.63;
p
= 0.02) and insulin (
r
= 0.78;
p
= 0.01) levels in the umbilical cord and with 1-min (
r
= 0.53;
p
= 0.0095) and 5-min (
r
= 0.69;
p
= 0.0003) Apgar scores. Placental TNF-α displayed a tendency to inversely correlate with fetal weight (
r
= −0.41;
p
= 0.05).
Conclusion
Compared to GM <100 mg/dL, GM ≥100 mg/dL was associated with a reduction in maternal IL-10 and TNF-α concentrations and increased placental TNF-α production. Placental IL-10 production was similar in both groups studied and directly correlated with hemoglobin and umbilical cord insulin levels, as well as with the 1- and 5-min Apgar scores.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>22205204</pmid><doi>10.1007/s10875-011-9634-3</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0271-9142 |
| ispartof | Journal of clinical immunology, 2012-06, Vol.32 (3), p.604-610 |
| issn | 0271-9142 1573-2592 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1017971196 |
| source | Springer Nature |
| subjects | Adult Biomedical and Life Sciences Biomedicine Blood Diabetes Mellitus, Type 2 - immunology Diabetes, Gestational - immunology Female Fetuses Hemoglobin Humans Hyperglycemia Hyperglycemia - immunology Immunology Infant, Newborn Infectious Diseases Insulin Insulin - blood Interleukin 10 Interleukin-10 - blood Interleukin-10 - immunology Internal Medicine Medical Microbiology Oxygen - metabolism Placenta Placenta - immunology Pregnancy Pregnancy in Diabetics - immunology Tumor necrosis factor- alpha Tumor Necrosis Factor-alpha - blood Tumor Necrosis Factor-alpha - immunology Umbilical cord Young Adult |
| title | Influence of Maternal Hyperglycemia on IL-10 and TNF-α Production: The Relationship with Perinatal Outcomes |
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