Harnessing gamma delta T cells in anticancer immunotherapy

gamma delta T lymphocytes are involved in the stress response to injured epithelia and in tissue homeostasis by limiting the dissemination of malignant or infected cells and by regulating the nature of the subsequent adaptive immune response. gamma delta T cells have potent MHC-unrestricted cytotoxi...

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Bibliographic Details
Published in:Trends in immunology 2012-05, Vol.33 (5), p.199-206
Main Authors: Hannani, Dalil, Ma, Yuting, Yamazaki, Takahiro, Dechanet-Merville, Julie, Kroemer, Guido, Zitvogel, Laurence
Format: Article
Language:English
Subjects:
Cancer
Cytokines
Cytotoxicity
Homeostasis
Immunotherapy
Lymphocytes T
Major histocompatibility complex
Receptor mechanisms
Reviews
Stress
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Summary:gamma delta T lymphocytes are involved in the stress response to injured epithelia and in tissue homeostasis by limiting the dissemination of malignant or infected cells and by regulating the nature of the subsequent adaptive immune response. gamma delta T cells have potent MHC-unrestricted cytotoxicity, a high potential for cytokine release and broad-spectrum recognition of cancer cells, and as such, are attractive effectors for cancer immunotherapy. Current expectations are going beyond ex vivo manipulation of the V gamma 9V delta 2 T subset, and target novel gamma delta T cell subsets, properties or receptors, to harness these unconventional T lymphocytes against cancer. This Opinion article discusses novel aspects of gamma delta T cell function during the course of anticancer therapies, as well as new avenues for their clinical implementation.
ISSN:1471-4906
DOI:10.1016/j.it.2012.01.006