Exposure measurement of aflatoxins and aflatoxin metabolites in human body fluids. A short review

Aflatoxins are highly toxic secondary fungal metabolites mainly produced by Aspergillus flavus and A. parasiticus. Human exposure to aflatoxins may result directly from ingestion of contaminated foods, or indirectly from consumption of foods from animals previously exposed to aflatoxins in feeds. Th...

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Bibliographic Details
Published in:Mycotoxin research 2012-05, Vol.28 (2), p.79-87
Main Authors: Leong, Yin-Hui, Latiff, Aishah A, Ahmad, Nurul Izzah, Rosma, Ahmad
Format: Article
Language:English
Subjects:
Aflatoxins
Aflatoxins - analysis
Aflatoxins - metabolism
Aspergillus flavus
Aspergillus flavus - metabolism
Aspergillus parasiticus
biomarkers
Biomarkers - analysis
Biomedical and Life Sciences
blood
Body fluids
Body Fluids - chemistry
Breast milk
Chemistry/Food Science
Diet
Eating
feeds
Food
Food Contamination
foods
Fungi
Human exposure
Humans
Ingestion
Life Sciences
Medical Microbiology
Medicine/Public Health
Metabolites
Microbiology
Review
Toxins
urine
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Summary:Aflatoxins are highly toxic secondary fungal metabolites mainly produced by Aspergillus flavus and A. parasiticus. Human exposure to aflatoxins may result directly from ingestion of contaminated foods, or indirectly from consumption of foods from animals previously exposed to aflatoxins in feeds. This paper focuses on exposure measurement of aflatoxins and aflatoxin metabolites in various human body fluids. Research on different metabolites present in blood, urine, breast milk, and other human fluids or tissues including their detection techniques is reviewed. The association between dietary intake of aflatoxins and biomarker measurement is also highlighted. Finally, aspects related to the differences between aflatoxin determination in food versus the biomarker approach are discussed.
ISSN:0178-7888
1867-1632
DOI:10.1007/s12550-012-0129-8