Host immune defense against Aspergillus fumigatus: insight from experimental systemic (disseminated) infection

Model of systemic Aspergillus fumigatus infection induced by intravenous application of conidia is suitable for studying important aspects of invasive aspergillosis including relationship between infection and mortality, dissemination of infection and immune mechanisms involved in host resistance to...

Full description

Saved in:
Bibliographic Details
Published in:Immunologic research 2012-04, Vol.52 (1-2), p.120-126
Main Authors: Mirkov, I., Stosic-Grujicic, S., Kataranovski, M.
Format: Article
Language:English
Subjects:
Adaptive Immunity
Allergology
Animals
Aspergillosis
Aspergillosis - immunology
Aspergillosis - mortality
Aspergillus fumigatus
Aspergillus fumigatus - immunology
Biomedical and Life Sciences
Biomedicine
Conidia
Cytokines
Disseminated infection
Drug development
Fungal infections
Humans
Immune response
Immune system
Immunology
Immunology in Serbia
Immunosuppressive agents
Internal Medicine
Intravenous administration
Macrophage Migration-Inhibitory Factors - immunology
Macrophages - immunology
Medicine/Public Health
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Inbred DBA
Mortality
Spleen
Spleen - immunology
T-Lymphocytes - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Model of systemic Aspergillus fumigatus infection induced by intravenous application of conidia is suitable for studying important aspects of invasive aspergillosis including relationship between infection and mortality, dissemination of infection and immune mechanisms involved in host resistance to this fungus. Use of this model allows the investigation of both innate and adaptive immune response characteristics in resistant/susceptible host, and investigating the contribution of genetic background and cytokine gene deficiency improves the knowledge of the diversity of mechanisms of immune response to Aspergillus infection. Studying of various aspects of systemic aspergillosis contributes to development of antifungal drugs.
ISSN:0257-277X
1559-0755
DOI:10.1007/s12026-012-8274-x