The potential of interleukin-17 to mediate hematopoietic response

It has long been known that T cells have the potential to modulate hematopoietic response in different ways. More recently, the importance of interleukin (IL)-17-secreting Th17 cells in T-cell-mediated regulation of hematopoiesis was indicated by the line of evidence that IL-17 links T-cell function...

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Bibliographic Details
Published in:Immunologic research 2012-04, Vol.52 (1-2), p.34-41
Main Authors: Krstic, Aleksandra, Mojsilovic, Slavko, Jovcic, Gordana, Bugarski, Diana
Format: Article
Language:English
Subjects:
Allergology
Animals
Biomedical and Life Sciences
Biomedicine
Bone marrow
Bone Marrow Cells
Cytokines
Data processing
Granulopoiesis
Helper cells
Hematopoiesis
Hematopoietic Stem Cells - physiology
Hematopoietic System - metabolism
Hemopoiesis
Humans
Immunology
Immunology in Serbia
Interleukin 17
Interleukin-17 - immunology
Internal Medicine
Leukocytes (neutrophilic)
Lymphocytes T
Medicine/Public Health
Mesenchymal Stromal Cells - metabolism
Mesenchyme
Molecular modelling
Neutrophils - metabolism
Spleen
Stem cells
T cell receptors
Th17 Cells - immunology
Th17 Cells - metabolism
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Summary:It has long been known that T cells have the potential to modulate hematopoietic response in different ways. More recently, the importance of interleukin (IL)-17-secreting Th17 cells in T-cell-mediated regulation of hematopoiesis was indicated by the line of evidence that IL-17 links T-cell function and hematopoiesis through stimulation of granulopoiesis and neutrophil trafficking. Furthermore, our data demonstrated that IL-17 also affects other cells of hematopoietic system, such as erythroid progenitors, as well as mesenchymal stem cells. In order to better understand the regulatory role of IL-17 in hematopoiesis, molecular mechanisms underlying the effects of IL-17 on hematopoietic and mesenchymal stem cells were also studied.
ISSN:0257-277X
1559-0755
DOI:10.1007/s12026-012-8276-8