Antimycobacterial activity of Usnea steineri and its major constituent (+)-usnic acid

The antimycobacterial activity of an extract of Usnea steineri and of its major constituent (+)-usnic acid was evaluated against Mycobacterium tuberculosis (ATCC 27294), Mycobacterium kansasii (ATCC 12478) and Mycobacterium avium (ATCC 15769). The acetone extract (ACE) of U. steineri displayed promi...

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Bibliographic Details
Published in:African journal of biotechnology 2012-03, Vol.11 (20), p.4636-4639
Main Authors: Lucarini, R, Tozatti, M G, de Oliveira Salloum, AI, Crotti, AEM, Silva, MLA, Gimenez, VMM, Groppo, M, Januario, AH, Martins, CHG, Cunha, W R
Format: Article
Language:English
Subjects:
Mycobacterium avium
Mycobacterium kansasii
Mycobacterium tuberculosis
Usnea
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Summary:The antimycobacterial activity of an extract of Usnea steineri and of its major constituent (+)-usnic acid was evaluated against Mycobacterium tuberculosis (ATCC 27294), Mycobacterium kansasii (ATCC 12478) and Mycobacterium avium (ATCC 15769). The acetone extract (ACE) of U. steineri displayed promising minimum inhibitory concentration (MIC) values of 32 mu g/ml against M. tuberculosis and 62 mu g/ml against both M. kansasii and M. avium. The isolated compound (+)-usnic acid was even more effective against the evaluated microorganisms with MIC values of 16 mu g/ml against M. avium and 8 mu g/ml against both M. tuberculosis and M. kansasii.
ISSN:1684-5315
1684-5315
DOI:10.5897/AJB11.3551