Protective effects of bone marrow mononuclear cell therapy on lung and heart in an elastase-induced emphysema model

Highlights ► Bone marrow cells had a protective effect on lung and heart in emphysema. ► Bone marrow cells modulated inflammation and remodeling in emphysema. ► Cardiac function improvement was associated with decreased fibrosis in lung vessels. ► Lung and heart protection might be attributed to par...

Full description

Saved in:
Bibliographic Details
Published in:Respiratory physiology & neurobiology 2012-06, Vol.182 (1), p.26-36
Main Authors: Cruz, Fernanda F, Antunes, Mariana A, Abreu, Soraia C, Fujisaki, Lívia C, Silva, Johnatas D, Xisto, Débora G, Maron-Gutierrez, Tatiana, Ornellas, Debora S, Sá, Vanessa K, Rocha, Nazareth N, Capelozzi, Vera L, Morales, Marcelo M, Rocco, Patricia R.M
Format: Article
Language:English
Subjects:
Airway Remodeling
Analysis of Variance
Animals
Bone Marrow Cells - cytology
Cardiovascular function
Caspase 3 - metabolism
Echocardiography
Elastase
Emphysema
Emphysema - chemically induced
Emphysema - metabolism
Emphysema - pathology
Emphysema - therapy
Female
Intercellular Signaling Peptides and Proteins - metabolism
Leukocytes, Mononuclear - transplantation
Lung - metabolism
Lung - pathology
Lymphocyte Subsets - cytology
Male
Medical Education
Mice
Mice, Inbred C57BL
Myocardium - metabolism
Myocardium - pathology
Pancreatic Elastase
Pulmonary Heart Disease - prevention & control
Pulmonary/Respiratory
Random Allocation
Remodeling
Stem cells
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights ► Bone marrow cells had a protective effect on lung and heart in emphysema. ► Bone marrow cells modulated inflammation and remodeling in emphysema. ► Cardiac function improvement was associated with decreased fibrosis in lung vessels. ► Lung and heart protection might be attributed to paracrine effects.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2012.01.002