Low-grade Myofibroblastic Sarcoma of the Maxillary Region in a Dog

A subcutaneous tumour was identified in the maxillary region of a 14-year-old mixed breed dog. This tumour had grown rapidly over 2weeks. Microscopically, the tumour had ill-defined borders and was composed of bundles and whorls of atypical spindle cells accompanied by abundant collagen fibres. Immu...

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Bibliographic Details
Published in:Journal of comparative pathology 2012-07, Vol.147 (1), p.42-45
Main Authors: Tsuchiya, T., Suzuki, K., Hojo, Y., Shiraki, A., Imaoka, M., Shibutani, M., Mitsumori, K.
Format: Article
Language:English
Subjects:
Actins - metabolism
Animals
Biomarkers, Tumor - metabolism
Calcium-Binding Proteins - metabolism
Calponins
dog
Dog Diseases - metabolism
Dog Diseases - pathology
Dogs
Fibrosarcoma - metabolism
Fibrosarcoma - pathology
Fibrosarcoma - veterinary
histopathology
Immunohistochemistry - methods
Immunohistochemistry - veterinary
Male
Maxillary Neoplasms - metabolism
Maxillary Neoplasms - pathology
Maxillary Neoplasms - veterinary
maxillary tumour
Microfilament Proteins - metabolism
myofibroblastic sarcoma
Myofibroblasts - metabolism
Myofibroblasts - pathology
Myosarcoma - metabolism
Myosarcoma - pathology
Myosarcoma - veterinary
Vimentin - metabolism
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Description
Summary:A subcutaneous tumour was identified in the maxillary region of a 14-year-old mixed breed dog. This tumour had grown rapidly over 2weeks. Microscopically, the tumour had ill-defined borders and was composed of bundles and whorls of atypical spindle cells accompanied by abundant collagen fibres. Immunohistochemically, neoplastic cells were immunoreactive for vimentin, α-smooth muscle actin and calponin and negative for S100 protein, von Willebrand factor, desmin and smoothelin. These results suggested that the neoplastic cells were derived from myofibroblasts and that the tumour was a low-grade myofibroblastic sarcoma.
ISSN:0021-9975
1532-3129
DOI:10.1016/j.jcpa.2011.09.002