Neonatal cutaneous disseminated aspergillosis in a preterm extremely-low-birth-weight infant with favourable outcome at 3-year follow-up: a case report

Summary Invasive disseminated neonatal aspergillosis is an uncommon disease, with only scattered reports in literature in the last few years. Here we report on a 25-week gestational age, 730 g at birth preterm female infant who developed on day-of-life 10 multiple cutaneous exhulcerative lesions in...

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Bibliographic Details
Published in:Early human development 2012-05, Vol.88, p.S65-S68
Main Authors: Manzoni, P, Rizzollo, S, Monetti, C, Carbonara, C, Priolo, C, Mastretta, E, Barberis, L, Galletto, P, Cigna, P, Leonessa, M.L, Sala, U, Gomirato, G, Mostert, M, Stronati, M, Ruffinazzi, G, Tzialla, C, Jacqz-Aigrain, E, Kaguelidou, F, Farina, D
Format: Article
Language:English
Subjects:
Advanced Basic Science
Amphotericin B - therapeutic use
Antifungal Agents - therapeutic use
aspergillosis
Aspergillosis - diagnosis
Aspergillosis - drug therapy
Cutaneous disseminated
Dermatomycoses - diagnosis
Dermatomycoses - drug therapy
Female
Follow-Up Studies
Humans
Infant, Extremely Low Birth Weight
Infant, Newborn
Infant, Premature, Diseases - diagnosis
Infant, Premature, Diseases - drug therapy
Infection
Itraconazole - therapeutic use
Liposomal amphotericin B
Neonatal and Perinatal Medicine
Preterm neonates
Treatment Outcome
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Summary:Summary Invasive disseminated neonatal aspergillosis is an uncommon disease, with only scattered reports in literature in the last few years. Here we report on a 25-week gestational age, 730 g at birth preterm female infant who developed on day-of-life 10 multiple cutaneous exhulcerative lesions in her right arm, trunk and abdomen. Early recognition and diagnosis of these lesions as a due to cutaneous initial symptom of cutaneous disseminated aspergillosis, as well as prompt treatment with Liposomal amphotericin B + Itraconazole, secured successful recovery from the systemic infection. Skin lesions healed without any surgical treatment. The infant was discharged in good health. Long-term follow-up at three years of age revealed normality of all neurodevelopmental and cognitive parameters. To our knowledge, this is one of the very few cases of survival, free from sequelae, for a preterm infant affected by neonatal cutaneous disseminated aspergillosis.
ISSN:0378-3782
1872-6232
DOI:10.1016/S0378-3782(12)70018-X