International Harmonization of Toxicologic Pathology Nomenclature: An Overview and Review of Basic Principles

The International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice is a global project that is publishing criteria for both proliferative and nonproliferative changes in laboratory animals. This paper presents a set of general suggestions for terminology across syst...

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Bibliographic Details
Published in:Toxicologic pathology 2012-06, Vol.40 (4_suppl), p.7S-13S
Main Authors: Mann, Peter C., Vahle, John, Keenan, Charlotte M., Baker, Julia F., Bradley, Alys E., Goodman, Dawn G., Harada, Takanori, Herbert, Ronald, Kaufmann, Wolfgang, Kellner, Rupert, Nolte, Thomas, Rittinghausen, Susanne, Tanaka, Takuji
Format: Article
Language:English
Subjects:
Animals
Internationality
Mice
Neoplasms
Pathology - standards
Rats
Terminology as Topic
Toxicity Tests
Toxicology - standards
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Summary:The International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice is a global project that is publishing criteria for both proliferative and nonproliferative changes in laboratory animals. This paper presents a set of general suggestions for terminology across systems. These suggestions include the use of diagnostic versus descriptive terms, modifiers, combination terms, and grading systems; and the use of thresholds, synonyms, and terminology for some processes that are common to several organ systems. The purpose of this paper is to help the reader understand some of the basic principles underlying the International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice process.
ISSN:0192-6233
1533-1601
DOI:10.1177/0192623312438738