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Differential time to positivity (DTTP) for the diagnosis of catheter-related bloodstream infection: do we need to obtain one or more peripheral vein blood cultures?
The ideal number of blood samples to be obtained from peripheral veins (PVs) when differential time to positivity (DTTP) is being performed is an unresolved issue and most institutions obtain a single set. Our objective was to assess the number of proven central line-associated bloodstream infection...
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| Published in: | European journal of clinical microbiology & infectious diseases 2012-07, Vol.31 (7), p.1367-1372 |
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| container_end_page | 1372 |
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| container_title | European journal of clinical microbiology & infectious diseases |
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| creator | Guembe, M. Rodríguez-Créixems, M. Sánchez-Carrillo, C. Martín-Rabadán, P. Bouza, E. |
| description | The ideal number of blood samples to be obtained from peripheral veins (PVs) when differential time to positivity (DTTP) is being performed is an unresolved issue and most institutions obtain a single set. Our objective was to assess the number of proven central line-associated bloodstream infection (CLABSI) episodes that would have been recovered if blood had been cultured from one or two PVs. We performed a retrospective study in patients with proven CLABSI in which catheter lumens and two or more PV blood cultures were taken simultaneously. We calculated the number of episodes that would have been recovered if the culture of one or more PV blood cultures had been artificially eliminated. During a period of 4 years, we collected 60 episodes of proven CLABSI. Overall, if one PV culture had been eliminated in patients with two or three PV blood cultures, we would have documented 91.8% (
p
= 0.362) and 96.9% (
p
> 0.999) of episodes, respectively. If we had eliminated two PV blood cultures in patients with three PV blood cultures, 90.8% (
p
> 0.999) of episodes would have been documented. When performing the DTTP technique to confirm CLABSI, a single paired PV blood culture was not associated with a significant number of missed CLABSI episodes. |
| doi_str_mv | 10.1007/s10096-011-1451-3 |
| format | article |
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p
= 0.362) and 96.9% (
p
> 0.999) of episodes, respectively. If we had eliminated two PV blood cultures in patients with three PV blood cultures, 90.8% (
p
> 0.999) of episodes would have been documented. When performing the DTTP technique to confirm CLABSI, a single paired PV blood culture was not associated with a significant number of missed CLABSI episodes.</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-011-1451-3</identifier><identifier>PMID: 22015990</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Aged ; Bacteremia - diagnosis ; Bacteria - isolation & purification ; Bacterial diseases ; Bacterial sepsis ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Blood ; Blood - microbiology ; Catheter-Related Infections - diagnosis ; Catheters ; Female ; Fungemia - diagnosis ; Fungi - isolation & purification ; General aspects ; Human bacterial diseases ; Human infectious diseases. Experimental studies and models ; Humans ; Infectious diseases ; Internal Medicine ; Male ; Medical instruments ; Medical Microbiology ; Medical sciences ; Microbiological Techniques - methods ; Microorganisms ; Middle Aged ; Nosocomial infections ; Retrospective Studies ; Time Factors ; Veins & arteries</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2012-07, Vol.31 (7), p.1367-1372</ispartof><rights>Springer-Verlag 2011</rights><rights>2015 INIST-CNRS</rights><rights>Springer-Verlag 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-e3a85e1f640c7043ee7c9375bc6ef18cc2fa25c6d3d03416b260b7ccf934b08e3</citedby><cites>FETCH-LOGICAL-c402t-e3a85e1f640c7043ee7c9375bc6ef18cc2fa25c6d3d03416b260b7ccf934b08e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25981142$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22015990$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guembe, M.</creatorcontrib><creatorcontrib>Rodríguez-Créixems, M.</creatorcontrib><creatorcontrib>Sánchez-Carrillo, C.</creatorcontrib><creatorcontrib>Martín-Rabadán, P.</creatorcontrib><creatorcontrib>Bouza, E.</creatorcontrib><title>Differential time to positivity (DTTP) for the diagnosis of catheter-related bloodstream infection: do we need to obtain one or more peripheral vein blood cultures?</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>The ideal number of blood samples to be obtained from peripheral veins (PVs) when differential time to positivity (DTTP) is being performed is an unresolved issue and most institutions obtain a single set. Our objective was to assess the number of proven central line-associated bloodstream infection (CLABSI) episodes that would have been recovered if blood had been cultured from one or two PVs. We performed a retrospective study in patients with proven CLABSI in which catheter lumens and two or more PV blood cultures were taken simultaneously. We calculated the number of episodes that would have been recovered if the culture of one or more PV blood cultures had been artificially eliminated. During a period of 4 years, we collected 60 episodes of proven CLABSI. Overall, if one PV culture had been eliminated in patients with two or three PV blood cultures, we would have documented 91.8% (
p
= 0.362) and 96.9% (
p
> 0.999) of episodes, respectively. If we had eliminated two PV blood cultures in patients with three PV blood cultures, 90.8% (
p
> 0.999) of episodes would have been documented. When performing the DTTP technique to confirm CLABSI, a single paired PV blood culture was not associated with a significant number of missed CLABSI episodes.</description><subject>Adult</subject><subject>Aged</subject><subject>Bacteremia - diagnosis</subject><subject>Bacteria - isolation & purification</subject><subject>Bacterial diseases</subject><subject>Bacterial sepsis</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood</subject><subject>Blood - microbiology</subject><subject>Catheter-Related Infections - diagnosis</subject><subject>Catheters</subject><subject>Female</subject><subject>Fungemia - diagnosis</subject><subject>Fungi - isolation & purification</subject><subject>General aspects</subject><subject>Human bacterial diseases</subject><subject>Human infectious diseases. Experimental studies and models</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical instruments</subject><subject>Medical Microbiology</subject><subject>Medical sciences</subject><subject>Microbiological Techniques - methods</subject><subject>Microorganisms</subject><subject>Middle Aged</subject><subject>Nosocomial infections</subject><subject>Retrospective Studies</subject><subject>Time Factors</subject><subject>Veins & arteries</subject><issn>0934-9723</issn><issn>1435-4373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp1kUuLFDEUhYMoTtv6A9zIBRHGRWleValyIzLjCwZ00a6LVOpmJkNVUiapkfk__lDTdvtAcJNAznfPPeQQ8pjRF4xS9TKVs2sqyljFZM0qcYdsmBR1JYUSd8mGdkJWneLihDxI6ZqWmVap--SEc8rqrqMb8v3cWYsRfXZ6guxmhBxgCclld-PyLZye73afn4MNEfIVwuj0pS9qgmDB6PKUMVYRJ51xhGEKYUw5op7BeYsmu-BfwRjgG4LHQhTzMGTtPASPUEznEBEWjG65wlgi3GDRfvqAWae8RkyvH5J7Vk8JHx3vLfny7u3u7EN18en9x7M3F5WRlOcKhW5rZLaR1CgqBaIynVD1YBq0rDWGW81r04xipEKyZuANHZQxtnzTQFsUW3J68F1i-Lpiyv3sksFp0h7DmnpGWSsaxQQv6NN_0OuwRl_S7SmlpKKlgy1hB8rEkFJE2y_RzTreFqjfV9gfKuxLhf2-wl6UmSdH53WYcfw98auzAjw7AjoZPdmovXHpD1d3LWNyH5EfuFQkf4nx74j_2_4DgCG1Kw</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Guembe, M.</creator><creator>Rodríguez-Créixems, M.</creator><creator>Sánchez-Carrillo, C.</creator><creator>Martín-Rabadán, P.</creator><creator>Bouza, E.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20120701</creationdate><title>Differential time to positivity (DTTP) for the diagnosis of catheter-related bloodstream infection: do we need to obtain one or more peripheral vein blood cultures?</title><author>Guembe, M. ; Rodríguez-Créixems, M. ; Sánchez-Carrillo, C. ; Martín-Rabadán, P. ; Bouza, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-e3a85e1f640c7043ee7c9375bc6ef18cc2fa25c6d3d03416b260b7ccf934b08e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Bacteremia - diagnosis</topic><topic>Bacteria - isolation & purification</topic><topic>Bacterial diseases</topic><topic>Bacterial sepsis</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood</topic><topic>Blood - microbiology</topic><topic>Catheter-Related Infections - diagnosis</topic><topic>Catheters</topic><topic>Female</topic><topic>Fungemia - diagnosis</topic><topic>Fungi - isolation & purification</topic><topic>General aspects</topic><topic>Human bacterial diseases</topic><topic>Human infectious diseases. 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Our objective was to assess the number of proven central line-associated bloodstream infection (CLABSI) episodes that would have been recovered if blood had been cultured from one or two PVs. We performed a retrospective study in patients with proven CLABSI in which catheter lumens and two or more PV blood cultures were taken simultaneously. We calculated the number of episodes that would have been recovered if the culture of one or more PV blood cultures had been artificially eliminated. During a period of 4 years, we collected 60 episodes of proven CLABSI. Overall, if one PV culture had been eliminated in patients with two or three PV blood cultures, we would have documented 91.8% (
p
= 0.362) and 96.9% (
p
> 0.999) of episodes, respectively. If we had eliminated two PV blood cultures in patients with three PV blood cultures, 90.8% (
p
> 0.999) of episodes would have been documented. When performing the DTTP technique to confirm CLABSI, a single paired PV blood culture was not associated with a significant number of missed CLABSI episodes.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22015990</pmid><doi>10.1007/s10096-011-1451-3</doi><tpages>6</tpages></addata></record> |
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| source | Springer Nature |
| subjects | Adult Aged Bacteremia - diagnosis Bacteria - isolation & purification Bacterial diseases Bacterial sepsis Biological and medical sciences Biomedical and Life Sciences Biomedicine Blood Blood - microbiology Catheter-Related Infections - diagnosis Catheters Female Fungemia - diagnosis Fungi - isolation & purification General aspects Human bacterial diseases Human infectious diseases. Experimental studies and models Humans Infectious diseases Internal Medicine Male Medical instruments Medical Microbiology Medical sciences Microbiological Techniques - methods Microorganisms Middle Aged Nosocomial infections Retrospective Studies Time Factors Veins & arteries |
| title | Differential time to positivity (DTTP) for the diagnosis of catheter-related bloodstream infection: do we need to obtain one or more peripheral vein blood cultures? |
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