Neurogenic Hypertension and Elevated Vertebrobasilar Arterial Resistance: Is There a Causative Link?

There is evidence of sympathetic overdrive in a significant proportion of patients with essential hypertension and an animal model of the condition, the spontaneously hypertensive rat (SHR). The reasons for this remain elusive. However, there is also evidence of narrowing of the arteries supplying t...

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Bibliographic Details
Published in:Current hypertension reports 2012-06, Vol.14 (3), p.261-269
Main Authors: Cates, Matthew J., Dickinson, C. John, Hart, Emma C. J., Paton, Julian F. R.
Format: Article
Language:English
Subjects:
Animals
Basilar Artery - physiopathology
Brain Stem - blood supply
Brain Stem - physiopathology
Cardiology
Family Medicine
General Practice
Humans
Hypertension
Hypertension - etiology
Internal Medicine
Medicine
Medicine & Public Health
Metabolic Diseases
Nephrology
Primary Care Medicine
Rats
Rats, Inbred SHR
Secondary Hypertension: Adrenal and Nervous System Mechanisms (S Oparil and Kh Berecek
Section Editors
Sympathetic Nervous System - physiopathology
Vascular Resistance - physiology
Vertebral Artery - physiopathology
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Summary:There is evidence of sympathetic overdrive in a significant proportion of patients with essential hypertension and an animal model of the condition, the spontaneously hypertensive rat (SHR). The reasons for this remain elusive. However, there is also evidence of narrowing of the arteries supplying the brainstem in the SHR and hypertensive humans. In this review, we discuss the possible role of brainstem hypoperfusion in driving increased sympathetic activity and hypertension.
ISSN:1522-6417
1534-3111
DOI:10.1007/s11906-012-0267-6