Cellular FLICE-like inhibitory proteins (c-FLIPs): Fine-tuners of life and death decisions

c-FLIP proteins (isoforms: c-FLIPL, c-FLIPS, and c-FLIPR) play an essential role in the regulation of death receptor (DR)-induced apoptosis and NF-κB activation. Here, we discuss multiple mechanisms by which c-FLIPs control NF-κB activation and the life/death decision made in cancer and immune cells...

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Bibliographic Details
Published in:Experimental cell research 2012-07, Vol.318 (11), p.1324-1331
Main Authors: Öztürk, Selcen, Schleich, Kolja, Lavrik, Inna N.
Format: Article
Language:English
Subjects:
Apoptosis
c-FLIP
Cancer
CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism
CASP8 and FADD-Like Apoptosis Regulating Protein - physiology
Caspase-8
Cellular biology
Death receptor
DISC
Humans
Immunology
NF-kappa B - metabolism
Protein Isoforms
Proteins
Signal Transduction
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Summary:c-FLIP proteins (isoforms: c-FLIPL, c-FLIPS, and c-FLIPR) play an essential role in the regulation of death receptor (DR)-induced apoptosis and NF-κB activation. Here, we discuss multiple mechanisms by which c-FLIPs control NF-κB activation and the life/death decision made in cancer and immune cells. We focus on the role of c-FLIP in cellular signaling. We concentrate on c-FLIP protein modifications as well as on the regulation of c-FLIP expression levels. Furthermore, we discuss in detail how the exact quantity and dynamics of different c-FLIP isoforms in the cell influence the induction of pro- versus anti-apoptotic pathways.
ISSN:0014-4827
1090-2422
DOI:10.1016/j.yexcr.2012.01.019