Prognostic Role of Twist, Slug, and Foxc2 Expression in Stage I Non–Small-Cell Lung Cancer After Curative Resection

• Published in: Clinical lung cancer 2012-07, Vol.13 (4), p.280-287
• Main Authors: Jiang, Wei, Pang, Xu-Guang, Wang, Qun, Shen, Ya-Xing, Chen, Xiao-Ke, Xi, Jun-Jie
• Format: Article
• Language: English
• Subjects: Aged; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Carcinoma, Non-Small-Cell Lung - diagnosis; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - metabolism; Epithelial-mesenchymal transition; Female; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - metabolism; Gene Expression Regulation, Neoplastic; Hematology, Oncology and Palliative Medicine; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Lung cancer; Lung Neoplasms - diagnosis; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Male; Marker; Middle Aged; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Prognosis; Pulmonary/Respiratory; Snail Family Transcription Factors; Transcription Factors - genetics; Transcription Factors - metabolism; Twist-Related Protein 1 - genetics; Twist-Related Protein 1 - metabolism
• ISSN: 1525-7304; 1938-0690
• DOI: 10.1016/j.cllc.2011.11.005

Micro-Abstract By using immunohistochemistry in tissue microarrays of 137 cases, we evaluated the prognostic power of a 3-marker epithelial-mesenchymal transition–related model in patients with stage I non–small-cell lung cancer who underwent radical surgical resection. The Twist/Slug/Foxc2 coexpression model accurately prognosticated these patients and may be helpful in refining current treatment strategy for stage I non–small-cell lung cancer.