XPA A23G polymorphism and susceptibility to cancer: a meta-analysis

• Published in: Molecular biology reports 2012-06, Vol.39 (6), p.6791-6799
• Main Authors: Liu, Jun, Zhang, Zhen, Cao, Xiao-Lin, Lei, Da-Peng, Wang, Zhong-Qiu, Jin, Tong, Pan, Xin-Liang
• Format: Article
• Language: English
• Subjects: Animal Anatomy; Animal Biochemistry; Biomedical and Life Sciences; breast neoplasms; Cancer; Case-Control Studies; colorectal neoplasms; DNA damage; DNA repair; esophageal neoplasms; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Histology; Humans; Life Sciences; lung neoplasms; Meta-analysis; Morphology; Neoplasms - genetics; Odds Ratio; Polymorphism; Polymorphism, Single Nucleotide; Publication Bias; risk; risk factors; Xeroderma Pigmentosum Group A Protein - genetics
• ISSN: 0301-4851; 1573-4978
• DOI: 10.1007/s11033-012-1504-4

Xeroderma pigmentosum group A (XPA) participates in modulating recognition of DNA damage during the DNA nucleotide excision repair process. The XPA A23G polymorphism has been investigated in case–control studies to evaluate the cancer risk attributed to the variant, but the results were conflicting. To clarify the effect of XPA A23G polymorphism in cancer risk, we conducted a meta-analysis that included 30 published case–control studies. Overall, no significant association of XPA A23G variant with cancer susceptibility was observed for any genetic model. However, significant association was observed for colorectal cancer (GG vs. AA: OR = 1.68, 95% CI = 1.15–2.44; dominant genetic model GG + AG vs. AA: OR = 1.54, 95% CI = 1.08–1.17), for breast cancer an increased but non-significant risk was found (GG vs. AA: OR = 1.27, 95% CI = 0.98–1.66; dominant genetic model GG + AG vs. AA: OR = 1.27, 95% CI = 0.99–1.63), and for head and neck cancer an increased risk was observed in recessive model (OR = 1.19, 95% CI = 1.02–1.38), whereas for lung cancer a significant reduced risk was observed (GG vs. AA: OR = 0.77, 95% CI = 0.66–0.90; dominant genetic model GG + AG vs. AA: OR = 0.76, 95% CI = 0.66–0.87), it’s noting that in Asian population the inverse association was more apparent. In addition, in Asian population for esophageal cancer a significant decreased risk was also found in dominant genetic model (OR = 0.55; 95% CI = 0.43–0.70) and for head and neck cancer an increased risk was observed in dominant genetic model (OR = 1.51, 95% CI = 1.03–2.23). The meta-analysis suggested that the XPA A23G G allele is a low-penetrant risk factor for cancer development.