Acute Liver Failure Due to Varicella Zoster Virus Infection After Lung Transplantation: A Case Report

Abstract Most adults are Varicella zoster virus (VZV)-positive at the age of 20 years. Some, however, remain antibody-negative and may develop primary chicken pox during adulthood. We report a patient with Williams-Campbell syndrome who underwent double-lung transplantation while being VZV-negative....

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Bibliographic Details
Published in:Transplantation proceedings 2012-06, Vol.44 (5), p.1457-1459
Main Authors: Verleden, G.M, Vos, R, Van Raemdonck, D.E, Laleman, W, Vanaudenaerde, B.M
Format: Article
Language:English
Subjects:
Acyclovir - therapeutic use
Adult
Antiviral Agents - therapeutic use
Biological and medical sciences
Bronchiectasis - complications
Chickenpox - complications
Chickenpox - diagnosis
Chickenpox - drug therapy
Chickenpox - transmission
Chickenpox - virology
Fatal Outcome
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Gastroenterology. Liver. Pancreas. Abdomen
Herpesvirus 3, Human - pathogenicity
Humans
Liver Failure, Acute - etiology
Liver Transplantation
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Lung Transplantation - adverse effects
Male
Medical sciences
Multiple Organ Failure - etiology
Other diseases. Semiology
Respiratory Insufficiency - etiology
Respiratory Insufficiency - surgery
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Time Factors
Tissue, organ and graft immunology
Waiting Lists
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Summary:Abstract Most adults are Varicella zoster virus (VZV)-positive at the age of 20 years. Some, however, remain antibody-negative and may develop primary chicken pox during adulthood. We report a patient with Williams-Campbell syndrome who underwent double-lung transplantation while being VZV-negative. One year after the successful procedure, he was admitted with fulminant hepatic failure and some cutaneous vesicles in his face. Despite a rapid diagnosis of VZV infection and treatment with acyclovir, his situation deteriorated within 24 hours and while awaiting an urgent liver transplantation, he developed multiple organ failure and died.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2011.12.077