Prediction of Acute Cellular Rejection by Peripheral Blood Eosinophilia in Pediatric Living Donor Liver Transplantation

• Published in: Transplantation proceedings 2012-06, Vol.44 (5), p.1341-1345
• Main Authors: Sanada, Y, Ushijima, K, Mizuta, K, Urahashi, T, Ihara, Y, Wakiya, T, Okada, N, Yamada, N, Egami, S, Hishikawa, S, Otomo, S, Sakamoto, K, Yasuda, Y, Kawarasaki, H
• Format: Article
• Language: English
• Subjects: Acute Disease; Adolescent; Analysis of Variance; Biological and medical sciences; Child; Child, Preschool; Eosinophilia - blood; Eosinophilia - diagnosis; Eosinophilia - etiology; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Graft Rejection - diagnosis; Graft Rejection - immunology; Hematologic and hematopoietic diseases; Humans; Immunity, Cellular; Infant; Japan; Liver Transplantation - adverse effects; Liver Transplantation - immunology; Liver, biliary tract, pancreas, portal circulation, spleen; Living Donors; Male; Medical sciences; Other diseases. Hematologic involvement in other diseases; Retrospective Studies; Risk Assessment; Risk Factors; Severity of Illness Index; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Time Factors; Tissue, organ and graft immunology; Treatment Outcome
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2012.01.132

Abstract Background Acute cellular rejection (ACR) is a common cause of morbidity following liver transplantation. Several reports have evaluated the predictive value of peripheral blood eosinophilia as a simple noninvasive diagnostic marker for ACR. This study examined whether the relative eosinophil counts (REC) predicted ACR in pediatric living donor liver transplantation (LDLT). Methods One hundred three patients underwent LDLT between May 2001 and December 2007. ACR were diagnosed based on the pathological findings. Results The incidence of ACR was 46.6% (48/103); ACR was diagnosed an average of 13.5 days after LDLT. The average REC at 4 and 2 days before the onset ACR (n = 39) within 30 postoperative day (POD) was 4.3% and 7.3%, respectively, and 9.0% at the onset. Patients with ACR showed significantly higher levels of REC compared with those free of ACR ( P = .039). REC thresholds of 10% at POD 7 displayed a sensitivity and specificity of ACR detection of 80% and 75%, respectively. Moreover, the accumulated morbidity ratio of ACR within 30 POD was significantly higher with REC >10% at POD 7 ( P = .007). Conclusion ACR within POD 30 should be considered when REC is >10% at POD 7 after LDLT.