Glutamatergic changes in the cerebral white matter associated with schizophrenic exacerbation

Ota M, Ishikawa M, Sato N, Hori H, Sasayama D, Hattori K, Teraishi T, Nakata Y, Kunugi H. Glutamatergic changes in the cerebral white matter associated with schizophrenic exacerbation. Objective:  Glutamatergic dysfunction in the brain has been implicated in the pathophysiology of schizophrenia. Thi...

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Published in:Acta psychiatrica Scandinavica 2012-07, Vol.126 (1), p.72-78
Main Authors: Ota, M., Ishikawa, M., Sato, N., Hori, H., Sasayama, D., Hattori, K., Teraishi, T., Nakata, Y., Kunugi, H.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Brain
Brain - metabolism
Brain - pathology
Brain Chemistry - physiology
Case-Control Studies
Disease Progression
exacerbation
Excitatory Amino Acids - metabolism
Excitatory Amino Acids - physiology
Female
Glutamic Acid - metabolism
Glutamic Acid - physiology
Glutamine - metabolism
Glutamine - physiology
glutamine + glutamate
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
Medical sciences
Middle Aged
Neurobiology
Neuroimaging
Neurotransmitters
Parietal Lobe - metabolism
Parietal Lobe - physiopathology
Physiological psychology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - metabolism
Schizophrenia - pathology
Schizophrenia - physiopathology
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Summary:Ota M, Ishikawa M, Sato N, Hori H, Sasayama D, Hattori K, Teraishi T, Nakata Y, Kunugi H. Glutamatergic changes in the cerebral white matter associated with schizophrenic exacerbation. Objective:  Glutamatergic dysfunction in the brain has been implicated in the pathophysiology of schizophrenia. This study was aimed to examine several brain chemical mediators, including Glx (glutamate + glutamine), using 1H magnetic resonance spectroscopy (MRS) in medicated patients with schizophrenia, with and without psychotic exacerbation. Method:  1H MRS was acquired in 24 patients with schizophrenia, with psychotic exacerbation; 22 patients without exacerbation; and 27 age‐ and sex‐matched healthy volunteers. The levels of metabolites were measured in the left frontal and inferior parietal white matter and compared across the three groups. Results:  The Glx level was significantly elevated in the left inferior parietal white matter in the patients with psychotic exacerbation in comparison with that in the healthy volunteers and the patients without exacerbation (P 
ISSN:0001-690X
1600-0447
DOI:10.1111/j.1600-0447.2012.01853.x