Notch signaling pathway regulates proliferation and differentiation of immortalized Müller cells under hypoxic conditions in vitro

Highlights ► Hypoxia induces proliferation of Müller cell line rMC-1. ► Hypoxia skews differentiation of rMC-1 towards a retinal progenitor lineage. ► Blocking Notch signaling after hypoxia increased neural regeneration of rMC-1. ► Blocking Notch signaling after hypoxia attenuates de-differentiation...

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Bibliographic Details
Published in:Neuroscience 2012-07, Vol.214, p.171-180
Main Authors: Wang, Z, Sugano, E, Isago, H, Murayama, N, Tamai, M, Tomita, H
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Differentiation - physiology
Cell Hypoxia - physiology
Cell Line, Transformed
Cell Proliferation
differentiation
Eye and associated structures. Visual pathways and centers. Vision
Fundamental and applied biological sciences. Psychology
hypoxia
Müller cells
Neuroglia - physiology
Neurology
Notch
proliferation
Rats
Receptors, Notch - physiology
Retina - cytology
Retina - physiology
Signal Transduction - physiology
Stem Cells - physiology
Vertebrates: nervous system and sense organs
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Summary:Highlights ► Hypoxia induces proliferation of Müller cell line rMC-1. ► Hypoxia skews differentiation of rMC-1 towards a retinal progenitor lineage. ► Blocking Notch signaling after hypoxia increased neural regeneration of rMC-1. ► Blocking Notch signaling after hypoxia attenuates de-differentiation of rMC-1.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.04.025