Solitary plasmacytoma of the larynx treated with radiotherapy: a case report

Solitary plasmacytomas are rare tumors accounting for less than 10% of plasma cell neoplasms. On initial presentation they must be differentiated from multiple myeloma. This can be difficult because a high percentage of these tumors may be associated with subsequent development of multiple myeloma....

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Bibliographic Details
Published in:Tumori 2012-03, Vol.98 (2), p.35e-38e
Main Authors: Ravo, Vincenzo, Calvanese, Maria Grazia, Manzo, Roberto, Cuomo, Maria Grazia, Cammarota, Fabrizio, Murino, Paola, Muto, Paolo
Format: Article
Language:English
Subjects:
Biopsy
Diagnosis, Differential
Humans
Laryngeal Neoplasms - diagnosis
Laryngeal Neoplasms - radiotherapy
Laryngeal Neoplasms - surgery
Laser Therapy
Male
Middle Aged
Multiple Myeloma - diagnosis
Plasmacytoma - diagnosis
Plasmacytoma - radiotherapy
Plasmacytoma - surgery
Radiotherapy, Adjuvant
Radiotherapy, Conformal - methods
Treatment Outcome
Vocal Cords - surgery
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Summary:Solitary plasmacytomas are rare tumors accounting for less than 10% of plasma cell neoplasms. On initial presentation they must be differentiated from multiple myeloma. This can be difficult because a high percentage of these tumors may be associated with subsequent development of multiple myeloma. We present a case of plasmacytoma of the larynx treated with surgery and radiotherapy. A 56-year-old man presented a solitary plasmacytoma of the larynx. The diagnosis was made by biopsy and the presence of a mass on the right side of the larynx was confirmed by computed tomography and whole-body positron-emission tomography. Soon after the biopsy the patient underwent a CO2 laser cordectomy. After the definitive histological confirmation, the patient was referred to our department for three-dimensional conformal radiotherapy (3DCRT) to the involved site with curative intent. The prescribed dose was 50 Gy. Five months after the 3DRTE treatment there was no CT or PET evidence of tumor, and examination by the otorhinolaryngologist confirmed the success of laser cordectomy and 3DRTE treatment. There were no long-term side effects of the treatment. Radiation therapy following CO2 laser cordectomy can achieve excellent locoregional control of solitary plasmacytoma of the larynx.
ISSN:2038-2529
DOI:10.1700/1088.11945