Fungal infection presenting as giant cell tubulointerstitial nephritis in kidney allograft

Giant cell tubulointerstitial nephritis in the kidney allograft caused by infection is rare, and donor‐transmitted infection in transplanted kidneys is also rare. In this case report, we describe an unusual histological manifestation of Candida albicans in the graft biopsy of a 53‐year‐old male kidn...

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Bibliographic Details
Published in:Transplant infectious disease 2012-06, Vol.14 (3), p.288-291
Main Authors: Bagnasco, S.M., Subramanian, A.K., Desai, N.M.
Format: Article
Language:English
Subjects:
Antifungal Agents - therapeutic use
biopsy
Candida
Candida albicans - isolation & purification
Candidiasis - drug therapy
Candidiasis - microbiology
donor-transmitted
giant cell
Humans
kidney transplant
Kidney Transplantation
Male
Middle Aged
Nephritis, Interstitial - drug therapy
Nephritis, Interstitial - microbiology
Tissue Donors
Transplantation, Homologous
Treatment Outcome
Urine - microbiology
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Summary:Giant cell tubulointerstitial nephritis in the kidney allograft caused by infection is rare, and donor‐transmitted infection in transplanted kidneys is also rare. In this case report, we describe an unusual histological manifestation of Candida albicans in the graft biopsy of a 53‐year‐old male kidney transplant recipient with decreased renal function 12 days post transplant. Several giant cells were present in the tubulointerstitial inflammation, as well as yeasts, with no evidence of rejection, and the histological diagnosis was confirmed by urine culture. Donor urine culture was positive for C. albicans, suggestive of a possible donor‐transmitted infection. Prompt antifungal treatment eradicated the infection, and averted systemic spread. To our knowledge, there are no previous reports of Candida infection with giant cell tubulointerstitial nephritis in human renal allograft.
ISSN:1398-2273
1399-3062
DOI:10.1111/j.1399-3062.2011.00676.x