Population dynamics and ORF3 gene evolution of porcine circovirus type 2 circulating in Korea

This study was conducted to investigate the status and population dynamics of porcine circovirus type 2 (PCV2) in Korea and to assess the molecular evolutionary pattern of the two biologically important, overlapping open reading frames, the ORF1 and ORF3 genes. A wide range of PCV2 genomic sequences...

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Bibliographic Details
Published in:Archives of virology 2012-05, Vol.157 (5), p.799-810
Main Authors: Nguyen, Van Giap, Kim, Hye Kwon, Moon, Hyoung Joon, Park, Seong Jun, Keum, Hyun Ok, Rho, Semi, Han, Jae Yeon, Park, Bong Kyun
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Circoviridae Infections - epidemiology
Circoviridae Infections - veterinary
Circoviridae Infections - virology
Circovirus - classification
Circovirus - genetics
Circovirus - isolation & purification
Demography
Evolution
Evolution, Molecular
Female
Fundamental and applied biological sciences. Psychology
Genes
Genomes
Genotype & phenotype
Hypotheses
Infections
Infectious Diseases
Male
Markov analysis
Medical Microbiology
Microbiology
Miscellaneous
Open Reading Frames
Original Article
Phylogenetics
Phylogeny
Population
Porcine circovirus
Proteins
Republic of Korea - epidemiology
Sequence Alignment
Swine
Swine Diseases - epidemiology
Swine Diseases - virology
Veterinary medicine
Viral Proteins - genetics
Virology
Viruses
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Summary:This study was conducted to investigate the status and population dynamics of porcine circovirus type 2 (PCV2) in Korea and to assess the molecular evolutionary pattern of the two biologically important, overlapping open reading frames, the ORF1 and ORF3 genes. A wide range of PCV2 genomic sequences (entire genome, ORF1, ORF2 and ORF3) collected between 2001 and 2010 were analyzed using the Bayesian Markov chain Monte Carlo and maximum-likelihood approaches. These techniques identified the PCV2d genotype and the 2Ek cluster of PCV2a in Korea for the first time. Second, the genotypic shift of PCV2b dominating over PCV2a likely occurred between 2002 and 2004 due to a population expansion of PCV2b. In the context of positive Darwinian selection, the results uncovered independent evolutionary patterns in the ORF3 gene compared to the overlapping ORF1 gene and new sites in the viral ORFs/proteins that might relate to differences in the biological properties of the PCV2 groups.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-012-1234-x