Naturally occurring himachalenes to benzocycloheptene amino vinyl bromide derivatives: as antidepressant molecules

A new series of benzocycloheptene amino vinyl bromide derivatives ( 9a – 9m ) were synthesized from isomeric mixture of himachalenes through two-step synthesis. The unusual structure of benzocycloheptene amino vinyl bromide derivative ( 9a ) was confirmed by NMR and X-ray crystallography analyses. T...

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Bibliographic Details
Published in:Molecular diversity 2012-05, Vol.16 (2), p.357-366
Main Authors: Chaudhary, Abha, Das, Pralay, Mishra, Awanish, Kaur, Pushpinder, Singh, Bikram, Goel, Rajesh K.
Format: Article
Language:English
Subjects:
Animals
Antidepressants
Antidepressive Agents - chemical synthesis
Antidepressive Agents - chemistry
Antidepressive Agents - pharmacology
Behavior, Animal - drug effects
Benzocycloheptenes - chemistry
Biochemistry
Biomedical and Life Sciences
Chemical compounds
Chemical reactions
Crystal structure
Female
Full-Length Paper
Life Sciences
Male
Mice
Models, Biological
Organic Chemistry
Pharmaceutical sciences
Pharmacy
Polymer Sciences
Sesquiterpenes - chemistry
Structure-Activity Relationship
Vinyl Compounds - chemistry
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Summary:A new series of benzocycloheptene amino vinyl bromide derivatives ( 9a – 9m ) were synthesized from isomeric mixture of himachalenes through two-step synthesis. The unusual structure of benzocycloheptene amino vinyl bromide derivative ( 9a ) was confirmed by NMR and X-ray crystallography analyses. The newly synthesized amino vinyl bromide derivatives of benzocycloheptene were further evaluated for their antidepressant activities. The compound 9c had shown significant reduction in the immobility period.
ISSN:1381-1991
1573-501X
DOI:10.1007/s11030-012-9372-3