Rationally Engineered Polymeric Cisplatin Nanoparticles for Improved Antitumor Efficacy

A novel PEG-functionalised poly-isobutylene-maleic acid (PEG-PIMA) copolymer, which can complex with cis-Pt(II) through a monocarboxylato and a coordinate bond has been used to engineer a novel NP. This complex self-assembles into a PEG-PIMA-cisplatin NP, and exhibits an IC sub(50) = 0.77 plus or mi...

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Bibliographic Details
Published in:Platinum metals review 2011-10, Vol.55 (4), p.276-276
Main Authors: Paraskar, A, Soni, S, Basu, S, Amarasiriwardena, C J, Lupoli, N, Srivats, S, Roy, R S, Sengupta, S
Format: Article
Language:English
Subjects:
Bonding
Cancer
Compartments
Copolymers
Effectiveness
Nanoparticles
Platinum metals
Online Access:Get full text
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Summary:A novel PEG-functionalised poly-isobutylene-maleic acid (PEG-PIMA) copolymer, which can complex with cis-Pt(II) through a monocarboxylato and a coordinate bond has been used to engineer a novel NP. This complex self-assembles into a PEG-PIMA-cisplatin NP, and exhibits an IC sub(50) = 0.77 plus or minus 0.11 mu M, comparable to that of free cisplatin (IC sub(50) = 0.44 plus or minus 0.09 mu M). The NPs are internalised into the endolysosomal compartment of cancer cells, and release cisplatin in a pH-dependent manner.
ISSN:0032-1400