The association between hepatitis C virus infection, genetic polymorphisms of oxidative stress genes and B-cell non-Hodgkin’s lymphoma risk in Egypt

• Published in: Infection, genetics and evolution genetics and evolution, 2012-08, Vol.12 (6), p.1189-1194
• Main Authors: Farawela, Hala, Khorshied, Mervat, Shaheen, Iman, Gouda, Heba, Nasef, Aya, Abulata, Nelly, Mahmoud, Hebat-Allah, Zawam, Hamdy M., Mousa, Somaia M.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Antioxidant enzymes; Antioxidants; B-NHL; Case-Control Studies; catalase; Chi-Square Distribution; confidence interval; DNA Mutational Analysis; Egypt - epidemiology; etiological agents; Female; genes; Genetic polymorphism; Genetic Predisposition to Disease; Genotype; glutathione peroxidase; HCV; Hepatitis C virus; Hepatitis C, Chronic - complications; Hepatitis C, Chronic - epidemiology; Hepatitis C, Chronic - genetics; Hepatitis C, Chronic - metabolism; Humans; inducible nitric oxide synthase; Lymphoma, B-Cell - epidemiology; Lymphoma, B-Cell - genetics; Lymphoma, B-Cell - metabolism; Lymphoma, B-Cell - virology; Male; Middle Aged; Mutation; myeloperoxidase; NHL risk; non-Hodgkin lymphoma; odds ratio; oxidative stress; Oxidative Stress - genetics; Oxidative stress genes; Oxidoreductases - genetics; patients; Polymorphism, Genetic; Risk; risk factors; screening; superoxide dismutase
• ISSN: 1567-1348; 1567-7257
• DOI: 10.1016/j.meegid.2012.04.007

► We study NHL risk conferred by HCV infection and oxidative stress genes polymorphism. ► HCV infection is a risk factor for NHL in Egypt. ► Concomitant HCV infection and GPX1 gene polymorphism have a pronounced NHL risk. ► Combined HCV infection and MPO gene polymorphism have a synergetic risk for NHL. Hepatitis C virus (HCV) has been postulated to be an etiological agent for lymphoid malignancies. Polymorphisms in oxidative stress genes as; superoxide dismutase (SOD2), glutathione peroxidase (GPX1), catalase (CAT), myeloperoxidase (MPO) and nitric oxide synthase (NOS2) may influence non-Hodgkin’s lymphoma (NHL) risk. HCV screening and polymorphisms in these five genes coding for antioxidant enzymes were studied in 100 Egyptian patients with B cell-NHL and 100 controls to clarify the association between HCV infection, oxidative stress genes polymorphisms and B cell-NHL risk. A significantly higher prevalence of HCV infection was detected among NHL patients relative to controls and this carried a 14-fold increased NHL risk (odds ratio (OR)=14.3, 95% confidence interval (CI)=5.4–38.3, p