Extravascular Injection of Sclerotic Agents does not Affect Vessels in the Rat: Experimental Implications for Percutaneous Sclerotherapy of Arteriovenous Malformations

• Published in: European journal of vascular and endovascular surgery 2012-07, Vol.44 (1), p.73-76
• Main Authors: Sato, D, Kurita, M, Ozaki, M, Kaji, N, Takushima, A, Harii, K
• Format: Article
• Language: English
• Subjects: Absolute ethanol; Animals; Arteriovenous malformation; Arteriovenous Malformations - therapy; Disease Models, Animal; Endothelium, Vascular - drug effects; Endothelium, Vascular - pathology; Epigastric Arteries - abnormalities; Epigastric Arteries - drug effects; Ethanol - administration & dosage; Ethanolamine oleate; Femoral Artery - abnormalities; Femoral Artery - drug effects; Femoral Vein - abnormalities; Femoral Vein - drug effects; Follow-Up Studies; Injections; Oleic Acids - administration & dosage; Polidocanol; Polyethylene Glycols - administration & dosage; Rats; Rats, Wistar; Sclerosing Solutions - administration & dosage; Sclerotherapy; Sclerotherapy - methods; Solvents - administration & dosage; Surgery; Tissue Adhesives; Treatment Outcome
• ISSN: 1078-5884; 1532-2165
• DOI: 10.1016/j.ejvs.2012.04.001

Abstract Objectives Sclerotherapy is useful for the treatment of arteriovenous vascular malformations. However, intravascular administration of sclerotic agents into small arteriovenous niduses is often difficult. Extravascular administration of sclerotic agents causes reduction of vascular flow on Doppler echo during clinical sclerotherapy. Therefore, we aimed to investigate whether the extravascular injection of sclerotic agents affects tiny vessels. Design Animal study. Materials The effect of extravascular injection of sclerotic agents on vessels was investigated using rat femoral and superficial inferior epigastric vessels. Methods After surgical exposure of vessels, absolute ethanol, 5% ethanolamine oleate and 3% polidocanol were injected into perivascular surrounding tissues, and their effect on vessels was evaluated after 14 days using histology and coloured silicone rubber injection. Results The integrity of the vascular lumen, endothelial cells and vascular patency were not affected by injection of sclerotic agents. Conclusions Attenuation of vascular flow of an arteriovenous shunt after extravascular injection of sclerotic agents is transient and/or trivial and does not cause disruption of vessels. Therefore, sclerotic agents should be delivered to obtain sufficient destruction of arteriovenous malformation lesions and blood flow.