Leukoencephalopathy, cerebral calcifications, and cysts: Case report

Complications are typically a consequence of mass effect including cerebral edema leading to intracranial hypertension, papilledema, syringomyelia and eventually tonsillar herniation [4].2 Case report A 42 year old woman, born two months premature with approximate weight of two pounds and a noncontr...

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Bibliographic Details
Published in:Clinical neurology and neurosurgery 2012-07, Vol.114 (6), p.806-809
Main Authors: Osman, Nadir I, Lorincz, Matthew T, Hulsing, Kerry L, Gebarski, Stephen S
Format: Article
Language:English
Subjects:
Adult
Anticonvulsants - therapeutic use
Basal Ganglia Diseases - complications
Biological and medical sciences
Brain
Brain - diagnostic imaging
Brain - pathology
Calcinosis - complications
Central Nervous System Cysts - complications
Cerebral calcifications
Cysts
Dystonia
Dystonia - complications
Female
Gait Disorders, Neurologic - etiology
Humans
Infant, Newborn
Infant, Premature
Leukoencephalopathies - complications
Leukoencephalopathy
Magnetic Resonance Imaging
Medical research
Medical sciences
Muscle Spasticity - complications
Neurologic Examination
Neurology
Neurosurgery
Piracetam - analogs & derivatives
Piracetam - therapeutic use
Seizures - complications
Seizures - drug therapy
Spasticity
Spinal Puncture
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tomography, X-Ray Computed
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Summary:Complications are typically a consequence of mass effect including cerebral edema leading to intracranial hypertension, papilledema, syringomyelia and eventually tonsillar herniation [4].2 Case report A 42 year old woman, born two months premature with approximate weight of two pounds and a noncontributory family history, presented to our general neurology clinic for second opinion after watching a TV show "Mysterious Diagnosis" about Segawa dystonia (juvenile dopa-responsive dystonia) to evaluate her longstanding dystonia, spasticity, and new onset tonic-clonic seizures. The CT (Fig. 2) showed progressive cysts, with local mass effect, and progressive bilateral diffuse coarse calcifications in the deep gray matter structures including bilateral thalami, basal ganglia, dentate nuclei, and superficial and deep white matter of the cerebral hemispheres.
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2011.12.049