Risk factors for mother-to-child transmission of hepatitis C virus: Maternal high viral load and fetal exposure in the birth canal

Aim:  Mother‐to‐child transmission (MTCT) is the major transmission pathway of hepatitis C virus (HCV) in children. However, its risk factors remain unsettled for introduction of putative intervention. Methods:  Pregnant women screened for HCV and MTCT in children born to antibody‐positive mothers w...

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Bibliographic Details
Published in:Hepatology research 2012-07, Vol.42 (7), p.648-657
Main Authors: Murakami, Jun, Nagata, Ikuo, Iitsuka, Toshiyuki, Okamoto, Manabu, Kaji, Shunsaku, Hoshika, Tadataka, Matsuda, Ryu, Kanzaki, Susumu, Shiraki, Kazuo, Suyama, Akihiko, Hino, Shigeo
Format: Article
Language:English
Subjects:
cesarean section
fetal membranes
hepatitis C virus
infectious disease transmission
premature rupture
vertical
viral load
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Summary:Aim:  Mother‐to‐child transmission (MTCT) is the major transmission pathway of hepatitis C virus (HCV) in children. However, its risk factors remain unsettled for introduction of putative intervention. Methods:  Pregnant women screened for HCV and MTCT in children born to antibody‐positive mothers were prospectively studied in Tottori, Japan. Results:  Among 41 856 screened women, 188 (0.45%) were HCV antibody‐positive, of whom 61% had detectable HCV RNA. While 10 of the 34 children (29%) born to high viral load (HVL: ≥6.0 × 105 IU/mL) mothers were infected, none born to RNA‐detectable but non‐HVL mothers were infected (P 
ISSN:1386-6346
1872-034X
DOI:10.1111/j.1872-034X.2012.00968.x