Pre-eclampsia following chemotherapy for breast cancer during pregnancy: case report and review of the literature

Purpose There has been some discussion about the effect of antineoplastic agents on the trophoblast, and whether this is associated with abnormal placental function such as an increased risk of pre-eclampsia/eclampsia. We discuss a possible causal relationship between chemotherapy for breast cancer...

Full description

Saved in:
Bibliographic Details
Published in:Archives of gynecology and obstetrics 2012-07, Vol.286 (1), p.89-92
Main Authors: Massey Skatulla, L., Loibl, S., Schauf, B., Müller, T.
Format: Article
Language:English
Subjects:
Adult
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Breast cancer
Breast Neoplasms - drug therapy
Carcinoma, Ductal, Breast - drug therapy
Case reports
Cesarean Section
Chemotherapy
Cyclophosphamide - administration & dosage
Endocrinology
Female
Gynecology
Health risk assessment
HELLP Syndrome - chemically induced
Human Genetics
Humans
Infant, Newborn
Male
Maternal-Fetal Medicine
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Pre-Eclampsia - chemically induced
Preeclampsia
Pregnancy
Pregnancy Complications, Neoplastic - drug therapy
Taxoids - administration & dosage
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose There has been some discussion about the effect of antineoplastic agents on the trophoblast, and whether this is associated with abnormal placental function such as an increased risk of pre-eclampsia/eclampsia. We discuss a possible causal relationship between chemotherapy for breast cancer during pregnancy and the development of pre-eclampsia based on the occurrence of both in a recent pregnancy. Methods We report the case of a 34-year-old gravida 4, para 1 with unilateral ductal invasive breast cancer, treated by surgery and subsequent chemotherapy during pregnancy. At 36 + 2 weeks of gestation a growth restricted male infant (1,680 g,
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-012-2257-y