Alcoholic hepatitis

Alcoholic hepatitis is one of the most severe presentations of alcoholic liver disease. It is usually revealed by the recent onset of jaundice in a patient with alcoholic cirrhosis. Maddrey's discriminant function can help to recognize patients with poor prognosis (the 6-month mortality is abov...

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Bibliographic Details
Published in:La revue de medecine interne 2012-06, Vol.33 (6), p.311-317
Main Authors: Trabut, J-B, Thépot, V, Sogni, P, Pol, S
Format: Article
Language:fre
Subjects:
Diagnosis, Differential
Diagnostic Imaging - methods
Disease Progression
Hepatitis, Alcoholic - complications
Hepatitis, Alcoholic - diagnosis
Hepatitis, Alcoholic - etiology
Hepatitis, Alcoholic - therapy
Humans
Infection - etiology
Infection - therapy
Prognosis
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Summary:Alcoholic hepatitis is one of the most severe presentations of alcoholic liver disease. It is usually revealed by the recent onset of jaundice in a patient with alcoholic cirrhosis. Maddrey's discriminant function can help to recognize patients with poor prognosis (the 6-month mortality is above 50% when it exceeds 32). Corticosteroids increase survival in those patients with high risk of death. Other treatments (pentoxifylline, N-acetyl-cysteine or enteral nutrition) need to be investigated further before to recommend their routine use instead of, or in association with, corticoids. Liver transplantation can be proposed to highly selected patients who do not respond to medical therapy. In any case, long-term prognosis will primarily depend on the maintenance of alcohol abstinence.
ISSN:1768-3122
DOI:10.1016/j.revmed.2012.02.002