Amide-Directed Tandem CC/CN Bond Formation through CH Activation

• Published in: Chemistry, an Asian journal an Asian journal, 2012-07, Vol.7 (7), p.1502-1514
• Main Authors: Zhu, Chen, Wang, Rui, Falck, John R.
• Format: Article
• Language: English
• Subjects: Activation; Alkenes - chemistry; Alkynes - chemistry; amides; Amides - chemistry; annulation; Carbon Monoxide - chemistry; Chemical bonds; Chemistry; Cyanides - chemistry; CC/CN bond formation; CH activation; heterocycles; Hydrocarbons, Aromatic - chemistry; Hydrogen bonds; Nitrogen; Organic chemistry
• ISSN: 1861-4728; 1861-471X
• DOI: 10.1002/asia.201200035

The transformation of CH bonds into other chemical bonds is of great significance in synthetic chemistry. CH bond‐activation processes provide a straightforward and atom‐economic strategy for the construction of complex structures; as such, they have attracted widespread interest over the past decade. As a prevalent directing group in the field of CH activation, the amide group not only offers excellent regiodirecting ability, but is also a potential CN bond precursor. As a consequence, a variety of nitrogen‐containing heterocycles have been obtained by using these reactions. This Focus Review addresses the recent research into the amide‐directed tandem CC/CN bond‐formation process through CH activation. The large body of research in this field over the past three years has established it as one of the most‐important topics in organic chemistry. Best director: CH activation reactions have received widespread interest over the past decade. This Focus Review addresses the recent developments in the amide‐directed tandem process of CC/CN bond formation through CH activation.