Global longitudinal strain aids the detection of non-obstructive coronary artery disease in the resting echocardiogram

To evaluate the diagnostic power of abnormal global longitudinal strain (GLS) to detect non-obstructive coronary artery disease (CAD) in the resting echocardiogram. GLS using two-dimensional speckle-tracking echocardiography (2D STE) is a powerful tool for detecting advanced CAD. However, the diagno...

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Bibliographic Details
Published in:European heart journal cardiovascular imaging 2012-07, Vol.13 (7), p.579-587
Main Authors: Montgomery, David E, Puthumana, Jyothy J, Fox, Justin M, Ogunyankin, Kofo O
Format: Article
Language:English
Subjects:
Area Under Curve
Coronary Angiography
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - physiopathology
Echocardiography - methods
Echocardiography, Stress
Electrocardiography
Female
Humans
Male
Middle Aged
Reproducibility of Results
Retrospective Studies
ROC Curve
Sensitivity and Specificity
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Summary:To evaluate the diagnostic power of abnormal global longitudinal strain (GLS) to detect non-obstructive coronary artery disease (CAD) in the resting echocardiogram. GLS using two-dimensional speckle-tracking echocardiography (2D STE) is a powerful tool for detecting advanced CAD. However, the diagnostic power of 2D STE for detecting moderate, clinically unapparent CAD from images obtained at rest is unknown. We retrospectively studied 2D STE characteristics in 123 consecutive patients who underwent stress echocardiography, and subsequently coronary angiography within 10 days. We compared the diagnostic power of GLS at rest to the conventional wall motion score index (WMSI) during stress for detecting stenosis ≥ 50% (CAD(>50)) in any major coronary artery. Studies with akinetic or dyskinetic segments and reduced left ventricular ejection fraction were excluded. In 56 patients with significant CAD(>50), GLS was -16.77 ± 3.18% compared with -19.05 ± 3.43% in the 67 patients without CAD(
ISSN:2047-2404
2047-2412
DOI:10.1093/ejechocard/jer282