ReGAE 7: long-term outcomes of augmented trabeculectomy with mitomycin C in African Caribbean patients

Background:  To evaluate long‐term outcomes and complication rates following trabeculectomy with mitomycin C in a case series of African Caribbean patients. Design:  A prospective, observational and non‐comparative case series. Participants:  Forty‐seven consecutive African Caribbean patients (47 ey...

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Bibliographic Details
Published in:Clinical & experimental ophthalmology 2012-05, Vol.40 (4), p.e176-e182
Main Authors: Shah, Peter, Agrawal, Pavi, Khaw, Peng T, Shafi, Fariha, Sii, Freda
Format: Article
Language:English
Subjects:
Adolescent
Adult
African Caribbean
African Continental Ancestry Group
Aged
Aged, 80 and over
Alkylating Agents - administration & dosage
Caribbean Region
Child
Combined Modality Therapy
Confidence intervals
Female
Follow-Up Studies
Glaucoma
Glaucoma - drug therapy
Glaucoma - ethnology
Glaucoma - surgery
Glaucoma - therapy
Humans
Intraocular Pressure - physiology
Intraoperative Complications
Male
Middle Aged
Mitomycin - administration & dosage
Postoperative Complications
Prospective Studies
Quality of life
Success
Survival analysis
Trabeculectomy
Treatment Outcome
Young Adult
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Summary:Background:  To evaluate long‐term outcomes and complication rates following trabeculectomy with mitomycin C in a case series of African Caribbean patients. Design:  A prospective, observational and non‐comparative case series. Participants:  Forty‐seven consecutive African Caribbean patients (47 eyes) with glaucoma. Methods:  All patients underwent augmented trabeculectomy with mitomycin C for uncontrolled intraocular pressure (IOP). Survival analysis was performed with a minimum of 12 months' follow up. Main Outcome Measures:  Surgical success was based upon IOP reduction to ≤21 mmHg, ≤18 mmHg and ≤15 mmHg without glaucoma medication (complete); or IOP reduction to ≤21 mmHg, ≤18 mmHg and ≤15 mmHg with or without glaucoma medication (qualified). Results:  The mean follow‐up period was 48.6 months. At 3 years post‐trabeculectomy 92.6% achieved a qualified success and 59.3% a complete success for an IOP ≤21 mmHg. At final follow up the mean IOP reduced from 33.7 mmHg to 13.1 mmHg (P 
ISSN:1442-6404
1442-9071
DOI:10.1111/j.1442-9071.2011.02639.x