Rapid assessment of influenza vaccine effectiveness: analysis of an internet-based cohort

The effectiveness of influenza vaccination programmes is seldom known during an epidemic. We developed an internet-based system to record influenza-like symptoms and response to infection in a participating cohort. Using self-reports of influenza-like symptoms and of influenza vaccine history and up...

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Bibliographic Details
Published in:Epidemiology and infection 2012-07, Vol.140 (7), p.1309-1315
Main Authors: EAMES, K. T. D., BROOKS-POLLOCK, E., PAOLOTTI, D., PEROSA, M., GIOANNINI, C., EDMUNDS, W. J.
Format: Article
Language:English
Subjects:
Absenteeism
Adolescent
Adult
Aged, 80 and over
Applied microbiology
Biological and medical sciences
Child
Child, Preschool
Cohort Studies
Data Collection - methods
Diseases
Estimates
Estimation methods
Female
Fundamental and applied biological sciences. Psychology
Health care industry
Health services
Humans
Illnesses
Immunization
Infant
Infant, Newborn
Infections
Influenza
Influenza vaccines
Influenza Vaccines - administration & dosage
Influenza Vaccines - immunology
Influenza, Human - pathology
Influenza, Human - prevention & control
Internet
Male
Methods
Microbiology
Middle Aged
Pandemics
Questionnaires
Respiratory diseases
Seasons
Sentinel surveillance
Surveillance
Symptoms
Vaccination
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Young Adult
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Summary:The effectiveness of influenza vaccination programmes is seldom known during an epidemic. We developed an internet-based system to record influenza-like symptoms and response to infection in a participating cohort. Using self-reports of influenza-like symptoms and of influenza vaccine history and uptake, we estimated vaccine effectiveness (VE) without the need for individuals to seek healthcare. We found that vaccination with the 2010 seasonal influenza vaccine was significantly protective against influenza-like illness (ILI) during the 2010–2011 influenza season (VE 52%, 95% CI 27–68). VE for individuals who received both the 2010 seasonal and 2009 pandemic influenza vaccines was 59% (95% CI 27–77), slightly higher than VE for those vaccinated in 2010 alone (VE 46%, 95% CI 9–68). Vaccinated individuals with ILI reported taking less time off work than unvaccinated individuals with ILI (3·4 days vs. 5·3 days, P
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268811001804