The effect of tigecycline and ertapenem against clinical isolates of Brucella melitensis detected by E-test on different media

In this study, in vitro activity of tigecycline (TIG) and ertapenem (ERT) against clinical isolates of Brucella melitensis and the effect of different media on in vitro test results were investigated. The in vitro effects of TIG and ERT to 38 B. melitensis isolates were comparatively investigated in...

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Bibliographic Details
Published in:Indian journal of medical microbiology 2010-10, Vol.28 (4), p.370-371
Main Authors: Tanyel, E, Coban, A. Y, Fisgin, N. Tasdelen, Tulek, N
Format: Article
Language:English
Subjects:
Agar
Antibiotics
Bacteria
Bacterial proteins
Blood
Brucella melitensis
Brucellosis
Brucellosis, tigecycline, ertapenem
Clinical isolates
Drugs
ertapenem
Minimum inhibitory concentration
Studies
tigecycline
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Summary:In this study, in vitro activity of tigecycline (TIG) and ertapenem (ERT) against clinical isolates of Brucella melitensis and the effect of different media on in vitro test results were investigated. The in vitro effects of TIG and ERT to 38 B. melitensis isolates were comparatively investigated in brucella agar and 5% sheep blood agar. MIC value of ERT was 0.032 μg/mL in 23 of 38 and 20 of 38 isolates on blood and brucella agar, respectively. Minimum inhibitory concentration values of TIG were substantially different ranging between 0.064-0.25 μg/mL on blood agar. However, MIC values of TIG were similar on brucella agar with 0.25 μg/mL in 15 of 38 isolates and 0.5 μg/mL in 10 of 38 isolates. In conclusion, although ERT and TIG were effective against B. melitensis isolates in vitro, further studies are needed in order to determine the use of these novel drugs in treatment of brucellosis.
ISSN:0255-0857
1998-3646
DOI:10.4103/0255-0857.71822