Chronic myeloid leukaemia and human immunodeficiency virus (HIV) infection

The occurrence of chronic myeloid leukaemia (CML) in patients infected with the human immunodeficiency virus (HIV) has rarely been reported in the literature. In this report, we describe the experience of a single centre in the management of 10 such patients, including demographic information, disea...

Full description

Saved in:
Bibliographic Details
Published in:International journal of hematology 2012-05, Vol.95 (5), p.556-563
Main Authors: Webb, Michael J., Barrett, Claire L., Pretorius, Christel, van Jaarsveld, Magdalena F., Louw, Vernon J.
Format: Article
Language:English
Subjects:
Adult
Aged
Anti-HIV Agents - therapeutic use
Antineoplastic Agents - therapeutic use
Biological and medical sciences
Chronic infection
Chronic myeloid leukemia
Cytogenetic Analysis
Cytogenetics
Demography
Drugs
Eosinophilia
Exanthema
Female
Hematologic and hematopoietic diseases
Hematology
HIV
HIV Infections - complications
HIV Infections - drug therapy
HIV-1 - drug effects
Human immunodeficiency virus
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Leukemia
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - complications
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Oncology
Original Article
Patient compliance
Patients
Retrospective Studies
Side effects
Signs and symptoms
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The occurrence of chronic myeloid leukaemia (CML) in patients infected with the human immunodeficiency virus (HIV) has rarely been reported in the literature. In this report, we describe the experience of a single centre in the management of 10 such patients, including demographic information, disease characteristics and response to therapy. We had a black female predominance in our series, with only a minority of patients achieving a complete cytogenetic response. The main reason for this appears to be compliance, which was influenced by distance to the treating centre. The side-effect profile was similar to that expected, with the exception of one patient who developed a drug rash with eosinophilia and systemic symptoms. Although CML patients co-morbid for HIV face certain unique challenges when compared to non-infected patients, their long-term outcome can be positive when appropriately managed.
ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-012-1073-2