Distribution, behavior and fate of azole antifungals during mechanical, biological, and chemical treatments in sewage treatment plants in China

• Published in: The Science of the total environment 2012-06, Vol.426, p.311-317
• Main Authors: Peng, Xianzhi, Huang, Qiuxin, Zhang, Kun, Yu, Yiyi, Wang, Zhifang, Wang, Chunwei
• Format: Article
• Language: English
• Subjects: Antifungal Agents - analysis; Antifungal Agents - chemistry; Applied sciences; Azole antifungals; Azoles - analysis; Azoles - chemistry; Biodegradation, Environmental; Biological and medical sciences; Biological treatment of waters; Biotechnology; Biotransformation; China; Clotrimazole - analysis; Clotrimazole - chemistry; Econazole - analysis; Econazole - chemistry; Environment and pollution; Environmental Monitoring; Exact sciences and technology; Fluconazole - analysis; Fluconazole - chemistry; Fundamental and applied biological sciences. Psychology; Industrial applications and implications. Economical aspects; Ketoconazole - analysis; Ketoconazole - chemistry; Miconazole - analysis; Miconazole - chemistry; Other wastewaters; Pollution; Sewage - chemistry; Sewage sludge; Sorption; Waste Disposal, Fluid - methods; Wastewater; Wastewaters; Water Pollutants, Chemical - analysis; Water Pollutants, Chemical - chemistry; Water treatment and pollution
• ISSN: 0048-9697; 1879-1026
• DOI: 10.1016/j.scitotenv.2012.03.067

Residue of azole antifungals in the environment is of concern due to the environmental risks and persistence. Distribution, behavior, and fate of frequently used azole antifungal pharmaceuticals were investigated in wastewater at two sewage treatment plants (STPs) in China. Fluconazole, clotrimazole, econazole, ketoconazole, and miconazole were constantly detected at 1–1834ngL−1 in the wastewater. The latter four were also ubiquitously detected in sewage sludge. Fluconazole passed through treatment in the STPs and largely remained in the final effluent. On the contrary, biotransformation and sorption to sludge occurred to the other azoles. Ketoconazole was more readily bio-transformed, whereas clotrimazole, econazole, and miconazole were more likely to be adsorbed onto and persisted in sewage sludge. Lipophilicity plays the governing role on adsorption. The highest concentrations in the raw wastewater were observed in winter for the azole pharmaceuticals except for fluconazole. The seasonal difference was smoothed out after treatment in the STPs. ► Azole antifungals are widely present in wastewater of China. ► Fluconazole passed through treatments and largely remained in the final effluent. ► Ketoconazole was more readily bio-transformed. ► Clotrimazole, econazole, and miconazole were more likely to be adsorbed to sludge. ► Lipophilicity plays the governing role on adsorption.