The biological characteristics of adult CD34+ acute promyelocytic leukemia

We aimed to explore the expression of CD34 and its impact on the disease outcome in patients with APL. The study comprised 40 de novo APL patients. Diagnostic tools included peripheral blood and bone marrow morphology and cytochemistry, immunophenotyping, cytogenetic studies, and PML/RARα fusion gen...

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Bibliographic Details
Published in:Medical oncology (Northwood, London, England) London, England), 2012-06, Vol.29 (2), p.1119-1126
Main Authors: Ahmad, Ebtesam Ibrahim, Akl, Hosneia kh, Hashem, Mona E., Elgohary, Tarek Ali M.
Format: Article
Language:English
Subjects:
Acute promyeloid leukemia
Adolescent
Adult
Aged
Antigens, CD34 - metabolism
Bone marrow
CD34 antigen
Cytochemistry
Female
Flow Cytometry
Fusion protein
Hematology
Humans
Immunophenotyping
Internal Medicine
Leukemia
Leukemia, Promyelocytic, Acute - classification
Leukemia, Promyelocytic, Acute - metabolism
Leukemia, Promyelocytic, Acute - mortality
Leukemia, Promyelocytic, Acute - therapy
Leukocytes
Male
Medicine
Medicine & Public Health
Middle Aged
Oncogene Proteins, Fusion - genetics
Oncology
Original Paper
Pathology
Peripheral blood
Polymerase chain reaction
Protein Isoforms
Remission
Remission Induction
Retinoic acid receptor alpha
Survival
Survival Rate
Treatment Outcome
Young Adult
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Summary:We aimed to explore the expression of CD34 and its impact on the disease outcome in patients with APL. The study comprised 40 de novo APL patients. Diagnostic tools included peripheral blood and bone marrow morphology and cytochemistry, immunophenotyping, cytogenetic studies, and PML/RARα fusion gene detection using RT-PCR. CD34 was expressed in 13 (32.5%) of cases with higher expression in M3v compared to M3 subtype. All M3v cases were CD34+, while only 7.4% of M3 cases were CD34+. CD34+ cases were associated with significant higher white blood cell count and peripheral blood promyelocytes. No significant association was found between PML/RAR-α isoform and molecular remission. CD34+ expression was significantly associated with decreased incidence of molecular remission and increased incidence of early death. The overall survival of patients with WBC count >11 × 103/μl was inferior to patients with WBC count
ISSN:1357-0560
1559-131X
DOI:10.1007/s12032-011-9895-y