Heme oxygenase microsatellite polymorphism, oxidative stress, glycemic control, and complication development in type 2 diabetes patients

Heme oxygenase-1 (HMOX-1) is activated by oxidative stress, and gene responsiveness is reportedly determined by the number of dinucleotide (GT(n)) repeats in its highly polymorphic promoter region. “Short” (S; GT(n)

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Bibliographic Details
Published in:Free radical biology & medicine 2012-07, Vol.53 (1), p.60-63
Main Authors: Choi, Siu-Wai, Fai Yeung, Vincent Tok, Benzie, Iris F.F.
Format: Article
Language:English
Subjects:
alleles
antioxidants
biomarkers
blood
Blood Glucose
death
Diabetes Complications - etiology
Diabetes Mellitus, Type 2 - genetics
Diabetes Mellitus, Type 2 - physiopathology
Diabetic complications
DNA damage
fasting
Female
Free radicals
Genetic Predisposition to Disease
Genotype
genotyping
glucose
glycemic control
glycohemoglobin
GT repeats
heme oxygenase (biliverdin-producing)
Heme oxygenase-1
Heme Oxygenase-1 - genetics
Humans
lipids
Male
microsatellite repeats
Microsatellite Repeats - genetics
Middle Aged
noninsulin-dependent diabetes mellitus
Oxidative Stress
patients
Polymorphism, Genetic - genetics
promoter regions
Promoter Regions, Genetic - genetics
risk
Risk Factors
Type 2 diabetes
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Description
Summary:Heme oxygenase-1 (HMOX-1) is activated by oxidative stress, and gene responsiveness is reportedly determined by the number of dinucleotide (GT(n)) repeats in its highly polymorphic promoter region. “Short” (S; GT(n)
ISSN:0891-5849
1873-4596
DOI:10.1016/j.freeradbiomed.2012.04.017