Effects of Angiotensin-Converting Enzyme Inhibitors and/or Beta Blockers on the Cardiomyopathy in Duchenne Muscular Dystrophy

• Published in: The American journal of cardiology 2012-07, Vol.110 (1), p.98-102
• Main Authors: Viollet, Laurence, PhD, Thrush, Philip T., MD, Flanigan, Kevin M., MD, Mendell, Jerry R., MD, Allen, Hugh D., MD
• Format: Article
• Language: English
• Subjects: ACE inhibitors; Adolescent; Adrenergic beta-Antagonists - administration & dosage; Adrenergic beta-Antagonists - therapeutic use; Adult; Angiotensin-Converting Enzyme Inhibitors - administration & dosage; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Beta blockers; Biological and medical sciences; Cardiology. Vascular system; Cardiomyopathies - diagnosis; Cardiomyopathies - drug therapy; Cardiomyopathies - etiology; Cardiovascular; Cardiovascular disease; Child; Clinical outcomes; Disease Progression; Diseases of striated muscles. Neuromuscular diseases; Dose-Response Relationship, Drug; Drug therapy; Drug Therapy, Combination; Echocardiography, Doppler; Electrocardiography, Ambulatory; Female; Follow-Up Studies; Glucocorticoids - therapeutic use; Heart; Humans; Male; Medical sciences; Muscular dystrophy; Muscular Dystrophy, Duchenne - complications; Muscular Dystrophy, Duchenne - drug therapy; Myocarditis. Cardiomyopathies; Neurology; Prospective Studies; Time Factors; Treatment Outcome; Ultrasonic imaging; Ventricular Function, Left - drug effects; Young Adult
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2012.02.064

Cardiomyopathy is a consequence of Duchenne muscular dystrophy (DMD). Suggested treatments include angiotensin-converting enzyme (ACE) inhibitors and/or β blockers (BBs), but few large series have been reported. We present 42 patients with DMD and cardiomyopathy treated with an ACE inhibitor or an ACE inhibitor plus a BB. Serial echocardiograms were recorded. Adequate ejection fractions (EFs) were obtained at initiation of therapy (EF