SIRT1 signaling as potential modulator of skeletal muscle diseases

Highlights ► In skeletal muscle diseases muscles undergo atrophy or wasting. ► The NAD-dependent protein deacetylase SIRT1 exerts pleiotropic beneficial effects. ► SIRT1 ameliorates muscle function during injury and aging. ► SIRT1 activity inhibits inflammatory processes, such as in muscular dystrop...

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Bibliographic Details
Published in:Current opinion in pharmacology 2012-06, Vol.12 (3), p.372-376
Main Authors: Tonkin, Joanne, Villarroya, Francesc, Puri, Pier Lorenzo, Vinciguerra, Manlio
Format: Article
Language:English
Subjects:
Aging - metabolism
Animals
Cell Proliferation
Disease Progression
Humans
Internal Medicine
Macrophages - immunology
Macrophages - metabolism
Medical Education
Muscle, Skeletal - immunology
Muscle, Skeletal - physiology
Muscle, Skeletal - physiopathology
Muscular Diseases - immunology
Muscular Diseases - metabolism
Muscular Diseases - physiopathology
Regeneration
Satellite Cells, Skeletal Muscle - immunology
Satellite Cells, Skeletal Muscle - physiology
Signal Transduction
Sirtuin 1 - chemistry
Sirtuin 1 - metabolism
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Summary:Highlights ► In skeletal muscle diseases muscles undergo atrophy or wasting. ► The NAD-dependent protein deacetylase SIRT1 exerts pleiotropic beneficial effects. ► SIRT1 ameliorates muscle function during injury and aging. ► SIRT1 activity inhibits inflammatory processes, such as in muscular dystrophy. ► SIRT1 activity governs macrophage and satellite cells functions in the muscle.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2012.02.010