Loading…

Dosimetric impact of fiducial markers in patients undergoing photon beam radiation therapy

Abstract Fiducial markers are widely used in image-guided radiation therapy to correct for setup error and organ motion. These markers, however, can cause dose perturbations in the target volume for patients undergoing external-beam radiation therapy. The goal of this study was to determine the dosi...

Full description

Saved in:
Bibliographic Details
Published in:Physica medica 2012-07, Vol.28 (3), p.240-244
Main Authors: Vassiliev, Oleg N, Kudchadker, Rajat J, Kuban, Deborah A, Frank, Steven J, Choi, Seungtaek, Nguyen, Quynh, Lee, Andrew K
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c477t-1d6e1cef39053556130e97fce11df3220af54f735276b3bd1a1859f2d2390f163
cites cdi_FETCH-LOGICAL-c477t-1d6e1cef39053556130e97fce11df3220af54f735276b3bd1a1859f2d2390f163
container_end_page 244
container_issue 3
container_start_page 240
container_title Physica medica
container_volume 28
creator Vassiliev, Oleg N
Kudchadker, Rajat J
Kuban, Deborah A
Frank, Steven J
Choi, Seungtaek
Nguyen, Quynh
Lee, Andrew K
description Abstract Fiducial markers are widely used in image-guided radiation therapy to correct for setup error and organ motion. These markers, however, can cause dose perturbations in the target volume for patients undergoing external-beam radiation therapy. The goal of this study was to determine the dosimetric impact of various types of fiducial markers commonly used in patients receiving photon radiation therapy. Monte Carlo simulations based on a newly developed EGSnrcMP user code were used to investigate three types of gold fiducial markers and a carbon marker. A single photon field with each fiducial in various orientations and two parallel-opposed beams were simulated at 6-MV and 18-MV energies. The results indicated that dose perturbations depended on marker size, material, and orientation, as well as on incident beam energy. Maximum dose perturbations were found for a single 6-MV beam. The increase in dose reached a factor of 1.58 near the upstream surface of the gold marker because of electron backscatter. At the downstream surface, the dose was reduced to a factor of 0.53 at the same point without the marker. For the 18-MV beam, the maximum dose factor was 1.48 and the minimum dose factor was 0.66. For the two parallel-opposed beams, the maximum dose reduction was within 5% at 6 MV and 2% at 18 MV. Dose enhancement, however, remained significant, reaching factors of 1.20 and 1.33 for the two energies near the fiducial surface. Carbon fiducials caused dose perturbations of only ∼1%.
doi_str_mv 10.1016/j.ejmp.2011.08.002
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1021127246</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S1120179711001189</els_id><sourcerecordid>1021127246</sourcerecordid><originalsourceid>FETCH-LOGICAL-c477t-1d6e1cef39053556130e97fce11df3220af54f735276b3bd1a1859f2d2390f163</originalsourceid><addsrcrecordid>eNp9kU1rFTEUhoNYbK3-AReSpZsZczI3kxkQQVo_CgUXKoibkJuctJnOTMYkU7j_3gy3unDRVRJ43pec5xDyClgNDNq3Q43DtNScAdSsqxnjT8gZSL6roIefT8sdOKtA9vKUPE9pYKzhXIhn5JRDJ0XH2Rn5dRmSnzBHb6ifFm0yDY46b1fj9UgnHe8wJupnuujscc6JrrPFeBP8fEOX25DDTPeoJxq19QUpz3yLUS-HF-TE6THhy4fznPz49PH7xZfq-uvnq4sP15XZSZkrsC2CQdf0TDRCtNAw7KUzCGBd-TDTTuycbASX7b7ZW9DQid5xy0vCQduckzfH3iWG3yumrCafDI6jnjGsSQHjRUTRsqH8iJoYUoro1BJ9mfFQILU5VYPanKrNqWKdKk5L6PVD_7qf0P6L_JVYgHdHAMuU9x6jSqaoMmh9RJOVDf7x_vf_xc3oZ2_0eIcHTENY41z8KVCJK6a-bVvdlgrASkvXN38AobudIQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1021127246</pqid></control><display><type>article</type><title>Dosimetric impact of fiducial markers in patients undergoing photon beam radiation therapy</title><source>ScienceDirect Freedom Collection</source><creator>Vassiliev, Oleg N ; Kudchadker, Rajat J ; Kuban, Deborah A ; Frank, Steven J ; Choi, Seungtaek ; Nguyen, Quynh ; Lee, Andrew K</creator><creatorcontrib>Vassiliev, Oleg N ; Kudchadker, Rajat J ; Kuban, Deborah A ; Frank, Steven J ; Choi, Seungtaek ; Nguyen, Quynh ; Lee, Andrew K</creatorcontrib><description>Abstract Fiducial markers are widely used in image-guided radiation therapy to correct for setup error and organ motion. These markers, however, can cause dose perturbations in the target volume for patients undergoing external-beam radiation therapy. The goal of this study was to determine the dosimetric impact of various types of fiducial markers commonly used in patients receiving photon radiation therapy. Monte Carlo simulations based on a newly developed EGSnrcMP user code were used to investigate three types of gold fiducial markers and a carbon marker. A single photon field with each fiducial in various orientations and two parallel-opposed beams were simulated at 6-MV and 18-MV energies. The results indicated that dose perturbations depended on marker size, material, and orientation, as well as on incident beam energy. Maximum dose perturbations were found for a single 6-MV beam. The increase in dose reached a factor of 1.58 near the upstream surface of the gold marker because of electron backscatter. At the downstream surface, the dose was reduced to a factor of 0.53 at the same point without the marker. For the 18-MV beam, the maximum dose factor was 1.48 and the minimum dose factor was 0.66. For the two parallel-opposed beams, the maximum dose reduction was within 5% at 6 MV and 2% at 18 MV. Dose enhancement, however, remained significant, reaching factors of 1.20 and 1.33 for the two energies near the fiducial surface. Carbon fiducials caused dose perturbations of only ∼1%.</description><identifier>ISSN: 1120-1797</identifier><identifier>EISSN: 1724-191X</identifier><identifier>DOI: 10.1016/j.ejmp.2011.08.002</identifier><identifier>PMID: 21875820</identifier><language>eng</language><publisher>Italy: Elsevier Ltd</publisher><subject>Carbon ; Dose perturbation ; Fiducial Markers ; Gold ; Humans ; Monte Carlo ; Photons - therapeutic use ; Radiology ; Radiometry ; Radiotherapy - standards</subject><ispartof>Physica medica, 2012-07, Vol.28 (3), p.240-244</ispartof><rights>Associazione Italiana di Fisica Medica</rights><rights>2011 Associazione Italiana di Fisica Medica</rights><rights>Copyright © 2011 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-1d6e1cef39053556130e97fce11df3220af54f735276b3bd1a1859f2d2390f163</citedby><cites>FETCH-LOGICAL-c477t-1d6e1cef39053556130e97fce11df3220af54f735276b3bd1a1859f2d2390f163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21875820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vassiliev, Oleg N</creatorcontrib><creatorcontrib>Kudchadker, Rajat J</creatorcontrib><creatorcontrib>Kuban, Deborah A</creatorcontrib><creatorcontrib>Frank, Steven J</creatorcontrib><creatorcontrib>Choi, Seungtaek</creatorcontrib><creatorcontrib>Nguyen, Quynh</creatorcontrib><creatorcontrib>Lee, Andrew K</creatorcontrib><title>Dosimetric impact of fiducial markers in patients undergoing photon beam radiation therapy</title><title>Physica medica</title><addtitle>Phys Med</addtitle><description>Abstract Fiducial markers are widely used in image-guided radiation therapy to correct for setup error and organ motion. These markers, however, can cause dose perturbations in the target volume for patients undergoing external-beam radiation therapy. The goal of this study was to determine the dosimetric impact of various types of fiducial markers commonly used in patients receiving photon radiation therapy. Monte Carlo simulations based on a newly developed EGSnrcMP user code were used to investigate three types of gold fiducial markers and a carbon marker. A single photon field with each fiducial in various orientations and two parallel-opposed beams were simulated at 6-MV and 18-MV energies. The results indicated that dose perturbations depended on marker size, material, and orientation, as well as on incident beam energy. Maximum dose perturbations were found for a single 6-MV beam. The increase in dose reached a factor of 1.58 near the upstream surface of the gold marker because of electron backscatter. At the downstream surface, the dose was reduced to a factor of 0.53 at the same point without the marker. For the 18-MV beam, the maximum dose factor was 1.48 and the minimum dose factor was 0.66. For the two parallel-opposed beams, the maximum dose reduction was within 5% at 6 MV and 2% at 18 MV. Dose enhancement, however, remained significant, reaching factors of 1.20 and 1.33 for the two energies near the fiducial surface. Carbon fiducials caused dose perturbations of only ∼1%.</description><subject>Carbon</subject><subject>Dose perturbation</subject><subject>Fiducial Markers</subject><subject>Gold</subject><subject>Humans</subject><subject>Monte Carlo</subject><subject>Photons - therapeutic use</subject><subject>Radiology</subject><subject>Radiometry</subject><subject>Radiotherapy - standards</subject><issn>1120-1797</issn><issn>1724-191X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kU1rFTEUhoNYbK3-AReSpZsZczI3kxkQQVo_CgUXKoibkJuctJnOTMYkU7j_3gy3unDRVRJ43pec5xDyClgNDNq3Q43DtNScAdSsqxnjT8gZSL6roIefT8sdOKtA9vKUPE9pYKzhXIhn5JRDJ0XH2Rn5dRmSnzBHb6ifFm0yDY46b1fj9UgnHe8wJupnuujscc6JrrPFeBP8fEOX25DDTPeoJxq19QUpz3yLUS-HF-TE6THhy4fznPz49PH7xZfq-uvnq4sP15XZSZkrsC2CQdf0TDRCtNAw7KUzCGBd-TDTTuycbASX7b7ZW9DQid5xy0vCQduckzfH3iWG3yumrCafDI6jnjGsSQHjRUTRsqH8iJoYUoro1BJ9mfFQILU5VYPanKrNqWKdKk5L6PVD_7qf0P6L_JVYgHdHAMuU9x6jSqaoMmh9RJOVDf7x_vf_xc3oZ2_0eIcHTENY41z8KVCJK6a-bVvdlgrASkvXN38AobudIQ</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Vassiliev, Oleg N</creator><creator>Kudchadker, Rajat J</creator><creator>Kuban, Deborah A</creator><creator>Frank, Steven J</creator><creator>Choi, Seungtaek</creator><creator>Nguyen, Quynh</creator><creator>Lee, Andrew K</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120701</creationdate><title>Dosimetric impact of fiducial markers in patients undergoing photon beam radiation therapy</title><author>Vassiliev, Oleg N ; Kudchadker, Rajat J ; Kuban, Deborah A ; Frank, Steven J ; Choi, Seungtaek ; Nguyen, Quynh ; Lee, Andrew K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-1d6e1cef39053556130e97fce11df3220af54f735276b3bd1a1859f2d2390f163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Carbon</topic><topic>Dose perturbation</topic><topic>Fiducial Markers</topic><topic>Gold</topic><topic>Humans</topic><topic>Monte Carlo</topic><topic>Photons - therapeutic use</topic><topic>Radiology</topic><topic>Radiometry</topic><topic>Radiotherapy - standards</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vassiliev, Oleg N</creatorcontrib><creatorcontrib>Kudchadker, Rajat J</creatorcontrib><creatorcontrib>Kuban, Deborah A</creatorcontrib><creatorcontrib>Frank, Steven J</creatorcontrib><creatorcontrib>Choi, Seungtaek</creatorcontrib><creatorcontrib>Nguyen, Quynh</creatorcontrib><creatorcontrib>Lee, Andrew K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Physica medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vassiliev, Oleg N</au><au>Kudchadker, Rajat J</au><au>Kuban, Deborah A</au><au>Frank, Steven J</au><au>Choi, Seungtaek</au><au>Nguyen, Quynh</au><au>Lee, Andrew K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dosimetric impact of fiducial markers in patients undergoing photon beam radiation therapy</atitle><jtitle>Physica medica</jtitle><addtitle>Phys Med</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>28</volume><issue>3</issue><spage>240</spage><epage>244</epage><pages>240-244</pages><issn>1120-1797</issn><eissn>1724-191X</eissn><abstract>Abstract Fiducial markers are widely used in image-guided radiation therapy to correct for setup error and organ motion. These markers, however, can cause dose perturbations in the target volume for patients undergoing external-beam radiation therapy. The goal of this study was to determine the dosimetric impact of various types of fiducial markers commonly used in patients receiving photon radiation therapy. Monte Carlo simulations based on a newly developed EGSnrcMP user code were used to investigate three types of gold fiducial markers and a carbon marker. A single photon field with each fiducial in various orientations and two parallel-opposed beams were simulated at 6-MV and 18-MV energies. The results indicated that dose perturbations depended on marker size, material, and orientation, as well as on incident beam energy. Maximum dose perturbations were found for a single 6-MV beam. The increase in dose reached a factor of 1.58 near the upstream surface of the gold marker because of electron backscatter. At the downstream surface, the dose was reduced to a factor of 0.53 at the same point without the marker. For the 18-MV beam, the maximum dose factor was 1.48 and the minimum dose factor was 0.66. For the two parallel-opposed beams, the maximum dose reduction was within 5% at 6 MV and 2% at 18 MV. Dose enhancement, however, remained significant, reaching factors of 1.20 and 1.33 for the two energies near the fiducial surface. Carbon fiducials caused dose perturbations of only ∼1%.</abstract><cop>Italy</cop><pub>Elsevier Ltd</pub><pmid>21875820</pmid><doi>10.1016/j.ejmp.2011.08.002</doi><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1120-1797
ispartof Physica medica, 2012-07, Vol.28 (3), p.240-244
issn 1120-1797
1724-191X
language eng
recordid cdi_proquest_miscellaneous_1021127246
source ScienceDirect Freedom Collection
subjects Carbon
Dose perturbation
Fiducial Markers
Gold
Humans
Monte Carlo
Photons - therapeutic use
Radiology
Radiometry
Radiotherapy - standards
title Dosimetric impact of fiducial markers in patients undergoing photon beam radiation therapy
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T13%3A36%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dosimetric%20impact%20of%20fiducial%20markers%20in%20patients%20undergoing%20photon%20beam%20radiation%20therapy&rft.jtitle=Physica%20medica&rft.au=Vassiliev,%20Oleg%20N&rft.date=2012-07-01&rft.volume=28&rft.issue=3&rft.spage=240&rft.epage=244&rft.pages=240-244&rft.issn=1120-1797&rft.eissn=1724-191X&rft_id=info:doi/10.1016/j.ejmp.2011.08.002&rft_dat=%3Cproquest_cross%3E1021127246%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c477t-1d6e1cef39053556130e97fce11df3220af54f735276b3bd1a1859f2d2390f163%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1021127246&rft_id=info:pmid/21875820&rfr_iscdi=true