Public–private partnerships in translational medicine: Concepts and practical examples

• Published in: Journal of controlled release 2012-07, Vol.161 (2), p.416-421
• Main Authors: Luijten, Peter R., van Dongen, Guus A.M.S., Moonen, Chrit T., Storm, Gert, Crommelin, Daan J.A.
• Format: Article
• Language: English
• Subjects: Animals; climate; diagnostic techniques; Drug Industry; drugs; HIFU; Humans; Image guided drug delivery; Magnetic Resonance Imaging; medicine; Molecular Imaging; MRI; Netherlands; new products; PET; Positron-Emission Tomography; Public-Private Sector Partnerships; Public–private partnerships; technology; translation (genetics); Translational Medical Research; ultrasonics; Universities
• ISSN: 0168-3659; 1873-4995
• DOI: 10.1016/j.jconrel.2012.03.012

The way forward in multidisciplinary research according to former NIH's director Elias Zerhouni is to engage in predictive, personalized, preemptive and participatory medicine. For the creation of the optimal innovation climate that would allow for such a strategy, public–private partnerships have been widely proposed as an important instrument. Public–private partnerships have become an important instrument to expedite translational research in medicine. The Netherlands have initiated three large public–private partnerships in the life sciences and health area to facilitate the translation of valuable basic scientific concepts to new products and services in medicine. The focus of these partnerships has been on drug development, improved diagnosis and regenerative medicine. The Dutch model of public–private partnership forms the blueprint of a much larger European initiative called EATRIS [1]. This paper will provide practical examples of public–private partnerships initiated to expedite the translation of new technology for drug development towards the clinic. Three specific technologies are in focus: companion diagnostics using nuclear medicine, the use of ultra high field MRI to generate sensitive surrogate endpoints based on endogenous contrast, and MRI guidance for High Intensity Focused Ultrasound mediated drug delivery. [Display omitted]