Myelodysplastic Syndrome/Acute Myeloid Leukemia With t(3;21)(q26.2;q22) Is Commonly a Therapy-Related Disease Associated With Poor Outcome

The t(3;21)(q26.2;q22) translocation is rare in cases of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). We studied 17 patients with MDS/AML associated with t(3;21) and compared them with 17 patients with MDS associated with inv(3) (q21q26.2)/t(3;3)(q21;q26.2), because these entitie...

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Bibliographic Details
Published in:American journal of clinical pathology 2012-07, Vol.138 (1), p.146-152
Main Authors: SHAOYING LI, CAMERON YIN, C, JEFFREY MEDEIROS, L, BUESO-RAMOS, Carlos, LU, Gary, PEI LIN
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Anemia - genetics
Anemia - mortality
Biological and medical sciences
Chromosome Aberrations
Chromosomes, Human, Pair 21
Chromosomes, Human, Pair 3
Female
Hematologic and hematopoietic diseases
Humans
Investigative techniques, diagnostic techniques (general aspects)
Leukemia, Myeloid, Acute - genetics
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
Myelodysplastic Syndromes - genetics
Myelodysplastic Syndromes - mortality
Myelodysplastic Syndromes - pathology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Prognosis
Translocation, Genetic
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Summary:The t(3;21)(q26.2;q22) translocation is rare in cases of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). We studied 17 patients with MDS/AML associated with t(3;21) and compared them with 17 patients with MDS associated with inv(3) (q21q26.2)/t(3;3)(q21;q26.2), because these entities share 3q26 locus abnormalities. The t(3;21) group included 9 men and 8 women, with a median age of 62 years (range, 13-81 years). One case was de novo AML and 16 cases were therapy-related, including 12 MDS (blasts,
ISSN:0002-9173
1943-7722
DOI:10.1309/AJCPZRRL2DGC2ODA