Increased inflammatory response and imbalance in blood and urinary oxidant–antioxidant status in South Indian women with gestational hypertension and preeclampsia

The objective of this study is to assess the association of blood and urinary oxidative stress parameters and inflammatory markers in women with gestational hypertension and preeclampsia. Malondialdehyde, protein bound sialic acid and C-reactive protein were estimated in serum and urine of pregnant...

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Bibliographic Details
Published in:Clinical biochemistry 2012-07, Vol.45 (10-11), p.835-838
Main Authors: Babu, M. Sathish, Bobby, Zachariah, Habeebullah, S.
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Antioxidants - metabolism
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Biomarkers - blood
Biomarkers - metabolism
Biomarkers - urine
Blood and lymphatic vessels
C-reactive protein
C-Reactive Protein - metabolism
Cardiology. Vascular system
Case-Control Studies
Diagnosis, Differential
Diseases of mother, fetus and pregnancy
Female
Gestational hypertension
Glutathione
Gynecology. Andrology. Obstetrics
Humans
Hypertension, Pregnancy-Induced - blood
Hypertension, Pregnancy-Induced - diagnosis
Hypertension, Pregnancy-Induced - urine
India
Investigative techniques, diagnostic techniques (general aspects)
Malondialdehyde
Malondialdehyde - blood
Malondialdehyde - metabolism
Malondialdehyde - urine
Medical sciences
N-Acetylneuraminic Acid - blood
N-Acetylneuraminic Acid - metabolism
N-Acetylneuraminic Acid - urine
Oxidants - blood
Oxidants - metabolism
Oxidants - urine
Oxidative Stress
Pre-Eclampsia - blood
Pre-Eclampsia - diagnosis
Pre-Eclampsia - urine
Preeclampsia
Pregnancy
Pregnancy. Fetus. Placenta
Protein bound sialic acid
Protein carbonyl
ROC Curve
Young Adult
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Summary:The objective of this study is to assess the association of blood and urinary oxidative stress parameters and inflammatory markers in women with gestational hypertension and preeclampsia. Malondialdehyde, protein bound sialic acid and C-reactive protein were estimated in serum and urine of pregnant women diagnosed with preeclampsia (n=30) and gestational hypertension (n=30) and the results were compared with 30 normal pregnant women. Whole blood glutathione level was reduced, and malondialdehyde and C-reactive protein levels were significantly higher and correlated with each other in preeclampsia (p
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2012.04.018