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Increased inflammatory response and imbalance in blood and urinary oxidant–antioxidant status in South Indian women with gestational hypertension and preeclampsia
The objective of this study is to assess the association of blood and urinary oxidative stress parameters and inflammatory markers in women with gestational hypertension and preeclampsia. Malondialdehyde, protein bound sialic acid and C-reactive protein were estimated in serum and urine of pregnant...
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| Published in: | Clinical biochemistry 2012-07, Vol.45 (10-11), p.835-838 |
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| container_issue | 10-11 |
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| container_title | Clinical biochemistry |
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| creator | Babu, M. Sathish Bobby, Zachariah Habeebullah, S. |
| description | The objective of this study is to assess the association of blood and urinary oxidative stress parameters and inflammatory markers in women with gestational hypertension and preeclampsia.
Malondialdehyde, protein bound sialic acid and C-reactive protein were estimated in serum and urine of pregnant women diagnosed with preeclampsia (n=30) and gestational hypertension (n=30) and the results were compared with 30 normal pregnant women.
Whole blood glutathione level was reduced, and malondialdehyde and C-reactive protein levels were significantly higher and correlated with each other in preeclampsia (p |
| doi_str_mv | 10.1016/j.clinbiochem.2012.04.018 |
| format | article |
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Malondialdehyde, protein bound sialic acid and C-reactive protein were estimated in serum and urine of pregnant women diagnosed with preeclampsia (n=30) and gestational hypertension (n=30) and the results were compared with 30 normal pregnant women.
Whole blood glutathione level was reduced, and malondialdehyde and C-reactive protein levels were significantly higher and correlated with each other in preeclampsia (p<0.05). Urinary malondialdehyde significantly correlated with urinary protein bound sialic acid in preeclampsia (r=0.412; p=0.02). Receiver operating curve analysis of serum protein bound sialic acid and serum malondialdehyde showed reasonable cutoff values for the differential diagnosis of preeclampsia.
Oxidative stress and inflammatory response are greater in women with preeclampsia in comparison to pregnant women with gestational hypertension and there is an association between oxidative stress and inflammatory response.
[Display omitted]
► MDA, protein carbonyl, hsCRP, protein bound sialic acid levels increased in HDP. ► GSH was decreased in preeclampsia and gestational hypertension. ► Urinary MDA was increased and uric acid decreased in preeclampsia and they correlated inversely. ► MDA of 25.1µmol/L is reasonable cutoff for differential diagnosis of preeclampsia. ► Sialic acid (4.04µg/mg protein) is reasonable cutoff for preeclampsia diagnosis.</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/j.clinbiochem.2012.04.018</identifier><identifier>PMID: 22561001</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Analysis of Variance ; Antioxidants - metabolism ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Biomarkers - blood ; Biomarkers - metabolism ; Biomarkers - urine ; Blood and lymphatic vessels ; C-reactive protein ; C-Reactive Protein - metabolism ; Cardiology. Vascular system ; Case-Control Studies ; Diagnosis, Differential ; Diseases of mother, fetus and pregnancy ; Female ; Gestational hypertension ; Glutathione ; Gynecology. Andrology. Obstetrics ; Humans ; Hypertension, Pregnancy-Induced - blood ; Hypertension, Pregnancy-Induced - diagnosis ; Hypertension, Pregnancy-Induced - urine ; India ; Investigative techniques, diagnostic techniques (general aspects) ; Malondialdehyde ; Malondialdehyde - blood ; Malondialdehyde - metabolism ; Malondialdehyde - urine ; Medical sciences ; N-Acetylneuraminic Acid - blood ; N-Acetylneuraminic Acid - metabolism ; N-Acetylneuraminic Acid - urine ; Oxidants - blood ; Oxidants - metabolism ; Oxidants - urine ; Oxidative Stress ; Pre-Eclampsia - blood ; Pre-Eclampsia - diagnosis ; Pre-Eclampsia - urine ; Preeclampsia ; Pregnancy ; Pregnancy. Fetus. Placenta ; Protein bound sialic acid ; Protein carbonyl ; ROC Curve ; Young Adult</subject><ispartof>Clinical biochemistry, 2012-07, Vol.45 (10-11), p.835-838</ispartof><rights>2012 The Canadian Society of Clinical Chemists</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-2c0d46b355ceb9cf1b0afce6fcad8542a665bdcd17174728d1b70837b1cb39bc3</citedby><cites>FETCH-LOGICAL-c407t-2c0d46b355ceb9cf1b0afce6fcad8542a665bdcd17174728d1b70837b1cb39bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26116937$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22561001$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Babu, M. Sathish</creatorcontrib><creatorcontrib>Bobby, Zachariah</creatorcontrib><creatorcontrib>Habeebullah, S.</creatorcontrib><title>Increased inflammatory response and imbalance in blood and urinary oxidant–antioxidant status in South Indian women with gestational hypertension and preeclampsia</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>The objective of this study is to assess the association of blood and urinary oxidative stress parameters and inflammatory markers in women with gestational hypertension and preeclampsia.
Malondialdehyde, protein bound sialic acid and C-reactive protein were estimated in serum and urine of pregnant women diagnosed with preeclampsia (n=30) and gestational hypertension (n=30) and the results were compared with 30 normal pregnant women.
Whole blood glutathione level was reduced, and malondialdehyde and C-reactive protein levels were significantly higher and correlated with each other in preeclampsia (p<0.05). Urinary malondialdehyde significantly correlated with urinary protein bound sialic acid in preeclampsia (r=0.412; p=0.02). Receiver operating curve analysis of serum protein bound sialic acid and serum malondialdehyde showed reasonable cutoff values for the differential diagnosis of preeclampsia.
Oxidative stress and inflammatory response are greater in women with preeclampsia in comparison to pregnant women with gestational hypertension and there is an association between oxidative stress and inflammatory response.
[Display omitted]
► MDA, protein carbonyl, hsCRP, protein bound sialic acid levels increased in HDP. ► GSH was decreased in preeclampsia and gestational hypertension. ► Urinary MDA was increased and uric acid decreased in preeclampsia and they correlated inversely. ► MDA of 25.1µmol/L is reasonable cutoff for differential diagnosis of preeclampsia. ► Sialic acid (4.04µg/mg protein) is reasonable cutoff for preeclampsia diagnosis.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Antioxidants - metabolism</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - metabolism</subject><subject>Biomarkers - urine</subject><subject>Blood and lymphatic vessels</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiology. Vascular system</subject><subject>Case-Control Studies</subject><subject>Diagnosis, Differential</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Gestational hypertension</subject><subject>Glutathione</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Hypertension, Pregnancy-Induced - blood</subject><subject>Hypertension, Pregnancy-Induced - diagnosis</subject><subject>Hypertension, Pregnancy-Induced - urine</subject><subject>India</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Malondialdehyde</subject><subject>Malondialdehyde - blood</subject><subject>Malondialdehyde - metabolism</subject><subject>Malondialdehyde - urine</subject><subject>Medical sciences</subject><subject>N-Acetylneuraminic Acid - blood</subject><subject>N-Acetylneuraminic Acid - metabolism</subject><subject>N-Acetylneuraminic Acid - urine</subject><subject>Oxidants - blood</subject><subject>Oxidants - metabolism</subject><subject>Oxidants - urine</subject><subject>Oxidative Stress</subject><subject>Pre-Eclampsia - blood</subject><subject>Pre-Eclampsia - diagnosis</subject><subject>Pre-Eclampsia - urine</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Protein bound sialic acid</subject><subject>Protein carbonyl</subject><subject>ROC Curve</subject><subject>Young Adult</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqNkUuO1DAQhi0EYpqBK6CwQGKTYDtOnCxRC4aWRmIBrC0_KrRbiR3sBJgdd-AKnGxOQvV081iyKavKX5V_10_IM0YrRln78lDZ0Qfjo93DVHHKeEVFRVl3j2xYJ-uS93V9n2wopX3ZM04vyKOcD5hy0bUPyQXnTcsoZRvycxdsAp3BFT4Mo54mvcR0UyTIcwwZCh3wZjJ61MECMoUZY3R35TX5oJGN37zTYbn9_gOjP2dFXvSy5mPH-7gu-2IXnNeh-BonwOix8gmOjI9Bj8X-Zoa0QMiY3g2fE4BFPXP2-jF5MOgxw5PzeUk-vnn9Yfu2vH53tdu-ui6toHIpuaVOtKZuGgumtwMzVA8W2sFq1zWC67ZtjLOOSSaF5J1jRtKuloZZU_fG1pfkxWnunOLnFdWpyWcLI_4d4poVo5wJ0UvRIdqfUJtizgkGNSc_4TYQUkeT1EH9Y5I6mqSoUGgS9j49P7OaCdyfzt-uIPD8DOhs9Tgk3L3Pf7mWsbavJXLbEwe4lC8eksrWA_rkfAK7KBf9f8j5BVvwvKA</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Babu, M. Sathish</creator><creator>Bobby, Zachariah</creator><creator>Habeebullah, S.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120701</creationdate><title>Increased inflammatory response and imbalance in blood and urinary oxidant–antioxidant status in South Indian women with gestational hypertension and preeclampsia</title><author>Babu, M. Sathish ; Bobby, Zachariah ; Habeebullah, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-2c0d46b355ceb9cf1b0afce6fcad8542a665bdcd17174728d1b70837b1cb39bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Antioxidants - metabolism</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Biomarkers - metabolism</topic><topic>Biomarkers - urine</topic><topic>Blood and lymphatic vessels</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiology. Vascular system</topic><topic>Case-Control Studies</topic><topic>Diagnosis, Differential</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Gestational hypertension</topic><topic>Glutathione</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Hypertension, Pregnancy-Induced - blood</topic><topic>Hypertension, Pregnancy-Induced - diagnosis</topic><topic>Hypertension, Pregnancy-Induced - urine</topic><topic>India</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Malondialdehyde</topic><topic>Malondialdehyde - blood</topic><topic>Malondialdehyde - metabolism</topic><topic>Malondialdehyde - urine</topic><topic>Medical sciences</topic><topic>N-Acetylneuraminic Acid - blood</topic><topic>N-Acetylneuraminic Acid - metabolism</topic><topic>N-Acetylneuraminic Acid - urine</topic><topic>Oxidants - blood</topic><topic>Oxidants - metabolism</topic><topic>Oxidants - urine</topic><topic>Oxidative Stress</topic><topic>Pre-Eclampsia - blood</topic><topic>Pre-Eclampsia - diagnosis</topic><topic>Pre-Eclampsia - urine</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Protein bound sialic acid</topic><topic>Protein carbonyl</topic><topic>ROC Curve</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Babu, M. Sathish</creatorcontrib><creatorcontrib>Bobby, Zachariah</creatorcontrib><creatorcontrib>Habeebullah, S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Babu, M. Sathish</au><au>Bobby, Zachariah</au><au>Habeebullah, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased inflammatory response and imbalance in blood and urinary oxidant–antioxidant status in South Indian women with gestational hypertension and preeclampsia</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>45</volume><issue>10-11</issue><spage>835</spage><epage>838</epage><pages>835-838</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>The objective of this study is to assess the association of blood and urinary oxidative stress parameters and inflammatory markers in women with gestational hypertension and preeclampsia.
Malondialdehyde, protein bound sialic acid and C-reactive protein were estimated in serum and urine of pregnant women diagnosed with preeclampsia (n=30) and gestational hypertension (n=30) and the results were compared with 30 normal pregnant women.
Whole blood glutathione level was reduced, and malondialdehyde and C-reactive protein levels were significantly higher and correlated with each other in preeclampsia (p<0.05). Urinary malondialdehyde significantly correlated with urinary protein bound sialic acid in preeclampsia (r=0.412; p=0.02). Receiver operating curve analysis of serum protein bound sialic acid and serum malondialdehyde showed reasonable cutoff values for the differential diagnosis of preeclampsia.
Oxidative stress and inflammatory response are greater in women with preeclampsia in comparison to pregnant women with gestational hypertension and there is an association between oxidative stress and inflammatory response.
[Display omitted]
► MDA, protein carbonyl, hsCRP, protein bound sialic acid levels increased in HDP. ► GSH was decreased in preeclampsia and gestational hypertension. ► Urinary MDA was increased and uric acid decreased in preeclampsia and they correlated inversely. ► MDA of 25.1µmol/L is reasonable cutoff for differential diagnosis of preeclampsia. ► Sialic acid (4.04µg/mg protein) is reasonable cutoff for preeclampsia diagnosis.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>22561001</pmid><doi>10.1016/j.clinbiochem.2012.04.018</doi><tpages>4</tpages></addata></record> |
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| ispartof | Clinical biochemistry, 2012-07, Vol.45 (10-11), p.835-838 |
| issn | 0009-9120 1873-2933 |
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| subjects | Adult Analysis of Variance Antioxidants - metabolism Arterial hypertension. Arterial hypotension Biological and medical sciences Biomarkers - blood Biomarkers - metabolism Biomarkers - urine Blood and lymphatic vessels C-reactive protein C-Reactive Protein - metabolism Cardiology. Vascular system Case-Control Studies Diagnosis, Differential Diseases of mother, fetus and pregnancy Female Gestational hypertension Glutathione Gynecology. Andrology. Obstetrics Humans Hypertension, Pregnancy-Induced - blood Hypertension, Pregnancy-Induced - diagnosis Hypertension, Pregnancy-Induced - urine India Investigative techniques, diagnostic techniques (general aspects) Malondialdehyde Malondialdehyde - blood Malondialdehyde - metabolism Malondialdehyde - urine Medical sciences N-Acetylneuraminic Acid - blood N-Acetylneuraminic Acid - metabolism N-Acetylneuraminic Acid - urine Oxidants - blood Oxidants - metabolism Oxidants - urine Oxidative Stress Pre-Eclampsia - blood Pre-Eclampsia - diagnosis Pre-Eclampsia - urine Preeclampsia Pregnancy Pregnancy. Fetus. Placenta Protein bound sialic acid Protein carbonyl ROC Curve Young Adult |
| title | Increased inflammatory response and imbalance in blood and urinary oxidant–antioxidant status in South Indian women with gestational hypertension and preeclampsia |
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